HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: TTC1 (Q99614)
Tetratricopeptide repeat protein 1 (TPR repeat protein 1)
Gene: TTC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~TPR_8
Common GO terms	GO:0005829 - cytosol GO:0006457 - protein folding GO:0051082 - unfolded protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 292
+	Hs
		111937 K9JA46_HUMAN (1-732): 0: 1087: 100.00		FKBP5_HUMAN (5-273): 9.22e-47: 164: 17.20
+	Hs
		431818 HS90A_HUMAN (1-732): 0: 1087: 100.00		FKBP5_HUMAN (5-273): 9.22e-47: 164: 17.20
+	Hs
		111936 K9JA46_HUMAN (1-732): 0: 1087: 100.00		FKBP4_HUMAN (29-282): 8.06e-45: 159: 18.02
+	Hs
		431755 HS90A_HUMAN (1-732): 0: 1087: 100.00		FKBP4_HUMAN (29-282): 8.06e-45: 159: 18.02
+	Hs
		432258 HS90A_HUMAN (1-732): 0: 1087: 100.00		UN45A_HUMAN (105-274): 2.21e-42: 157: 27.65
+	Mm
		432409 HS90A_MOUSE (1-732): 0: 1083: 97.82		FKBP4_MOUSE (3-264): 7.13e-45: 159: 16.54
+	Hs
		111940 K9JA46_HUMAN (1-732): 0: 1087: 100.00		UN45B_HUMAN (115-260): 3.41e-41: 153: 32.19
+	Hs
		432038 HS90A_HUMAN (1-732): 0: 1087: 100.00		UN45B_HUMAN (115-260): 3.41e-41: 153: 32.19
+	Hs
		432268 HS90A_HUMAN (1-732): 0: 1087: 100.00		RPAP3_HUMAN (72-252): 7.36e-41: 151: 24.86
+	Hs
		111935 K9JA46_HUMAN (1-732): 0: 1087: 100.00		PPP5_HUMAN (91-287): 1.25e-38: 143: 23.23
+	Hs
		431681 HS90A_HUMAN (1-732): 0: 1087: 100.00		PPP5_HUMAN (91-287): 1.25e-38: 143: 23.23
+	Hs
		432312 HS90A_HUMAN (1-732): 0: 1087: 100.00		AIPL1_HUMAN (10-253): 2.19e-38: 140: 19.70
+	Mm
		432427 HS90A_MOUSE (1-732): 0: 1083: 97.82		PPP5_MOUSE (91-287): 7.88e-39: 144: 22.22
+	Hs
		431781 HS90A_HUMAN (1-732): 0: 1087: 100.00		PPID_HUMAN (19-251): 1.93e-37: 138: 17.07
+	Mm
		513680 HS90B_MOUSE (19-732): 0: 1063: 86.98		PPP5_MOUSE (91-287): 7.88e-39: 144: 22.22
+	Hs
		431774 HS90A_HUMAN (1-732): 0: 1087: 100.00		SPAG1_HUMAN (118-267): 7.47e-28: 114: 26.00
+	Hs
		431886 HS90A_HUMAN (1-732): 0: 1087: 100.00		TOM34_HUMAN (119-236): 1.86e-14: 73.9: 38.02
+	Hs
		297024 HS90A_HUMAN (1-732): 0: 1087: 100.00		TOM70_HUMAN (120-215): 6.68e-14: 73.6: 39.58
+	Hs
		213451 HS90A_HUMAN (1-732): 0: 1087: 100.00		SGTA_HUMAN (39-204): 5.37e-14: 73: 13.25
+	Hs
		432195 HS90A_HUMAN (1-732): 0: 1087: 100.00		DNJC7_HUMAN (120-221): 1.37e-11: 66.6: 37.26