HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: NPAS2 (Q99743)
Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Basic-helix-loop-helix-PAS protein MOP4) (Class E basic helix-loop-helix protein 9) (bHLHe9) (Member of PAS protein 4) (PAS domain-containing protein 4)
Gene: NPAS2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	9079689
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0009410 - response to xenobiotic stimulus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 824
+	Mm
		432431 HS90A_MOUSE (1-732): 0: 1083: 97.82		HIF1A_MOUSE (2-798): 4.47e-128: 405: 15.14
+	Hs
		431903 HS90A_HUMAN (1-732): 0: 1087: 100.00		HIF1A_HUMAN (2-798): 6.81e-126: 399: 16.22
+	Hs
		431737 HS90A_HUMAN (1-732): 0: 1087: 100.00		SIM1_HUMAN (11-728): 1.55e-122: 389: 14.38
+	Mm
		432429 HS90A_MOUSE (1-732): 0: 1083: 97.82		SIM1_MOUSE (11-728): 4.56e-119: 379: 14.93
+	Hs
		438217 HS90B_HUMAN (19-732): 0: 1059: 86.13		HIF1A_HUMAN (2-798): 6.81e-126: 399: 16.22
+	Hs
		126097 HS90A_HUMAN (1-732): 0: 1087: 100.00		BMAL1_HUMAN (2-480): 6.13e-113: 359: 23.17
+	Hs
		431844 HS90A_HUMAN (1-732): 0: 1087: 100.00		SIM2_HUMAN (11-690): 5.39e-106: 342: 16.26
+	Hs
		432201 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPAS1_HUMAN (2-727): 1.35e-102: 338: 16.15
+	Hs
		431556 HS90A_HUMAN (1-732): 0: 1087: 100.00		ARNT_HUMAN (5-667): 1.9e-101: 333: 20.31
+	Mm
		432410 HS90A_MOUSE (1-732): 0: 1083: 97.82		AHR_MOUSE (14-808): 2.17e-99: 329: 16.55
+	Rn
		783943 HS90A_RAT (1-732): 0: 1085: 97.95		AHR_RAT (14-808): 5.44e-98: 326: 16.88
+	Hs
		438165 HS90B_HUMAN (19-732): 0: 1059: 86.13		SIM2_HUMAN (11-690): 5.39e-106: 342: 16.26
+	Mm
		513659 HS90B_MOUSE (19-732): 0: 1063: 86.98		AHR_MOUSE (14-808): 2.17e-99: 329: 16.55
+	Hs
		431594 HS90A_HUMAN (1-732): 0: 1087: 100.00		AHR_HUMAN (14-803): 3.49e-89: 302: 14.44
+	Hs
		432385 HS90A_HUMAN (1-732): 0: 1087: 100.00		HIF3A_HUMAN (1-672): 1.68e-83: 282: 16.47
+	Hs
		438468 HS90B_HUMAN (19-732): 0: 1059: 86.13		NPAS1_HUMAN (8-497): 1.38e-75: 258: 14.44
+	Dm
		365490 HSP83_DROME (15-732): 0: 1034: 78.41		Q9VXW7_DROME (1-491): 2.72e-75: 265: 19.82
+	Dm
		1096504 Q9VAY2_DROME (15-700): 0: 537: 46.13		SIMA_DROME (3-497): 1.2e-75: 271: 19.29