HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: Q9BVE2 (Q9BVE2)
CDC2L5 protein
Gene: Q9BVE2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 324
+	Hs
		431840 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK13_HUMAN (4-319): 7.18e-119: 375: 97.79
+	Hs
		438162 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK13_HUMAN (4-319): 7.18e-119: 375: 97.79
+	Hs
		431549 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK2_HUMAN (88-321): 1.52e-115: 337: 43.83
+	Hs
		431741 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK3_HUMAN (88-323): 2.96e-115: 337: 43.88
+	Hs
		414683 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK1_HUMAN (88-322): 1.64e-108: 319: 41.77
+	Hs
		431743 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK5_HUMAN (88-323): 4.06e-108: 318: 40.93
+	Hs
		437908 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK2_HUMAN (88-321): 1.52e-115: 337: 43.83
+	Hs
		438075 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK3_HUMAN (88-323): 2.96e-115: 337: 43.88
+	Hs
		438077 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK5_HUMAN (88-323): 4.06e-108: 318: 40.93
+	Hs
		431663 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK9_HUMAN (88-314): 2.05e-95: 289: 51.30
+	Mm
		432453 HS90A_MOUSE (1-732): 0: 1083: 97.82		CDK9_MOUSE (90-314): 1.02e-94: 287: 50.88
+	Mm
		513701 HS90B_MOUSE (19-732): 0: 1063: 86.98		CDK9_MOUSE (90-314): 1.02e-94: 287: 50.88
+	Hs
		438005 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK9_HUMAN (88-314): 2.05e-95: 289: 51.30
+	Hs
		538107 ENPL_HUMAN (14-701): 0: 898: 46.78		CDK2_HUMAN (88-321): 1.52e-115: 337: 43.83
+	Ca
		804548 HSP90_CANAL (12-732): 0: 914: 60.50		Q5AJH3_CANAL (97-309): 5.09e-66: 219: 52.32
+	Hs
		1047605 H90B3_HUMAN (19-732): 0: 728: 65.41		CDK13_HUMAN (4-319): 7.18e-119: 375: 97.79
+	Hs
		841763 H90B3_HUMAN (19-732): 0: 728: 65.41		CDK9_HUMAN (88-314): 2.05e-95: 289: 51.30
+	Hs
		960137 H90B3_HUMAN (19-732): 0: 728: 65.41		CDKL1_HUMAN (88-323): 1.04e-94: 286: 38.14
+	Hs
		960099 H90B4_HUMAN (30-604): 0: 571: 62.61		CDK3_HUMAN (88-323): 2.96e-115: 337: 43.88
+	Hs
		841762 H90B4_HUMAN (30-604): 0: 571: 62.61		CDK9_HUMAN (88-314): 2.05e-95: 289: 51.30