HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: RPAP3 (Q9H6T3)
RNA polymerase II-associated protein 3
Gene: RPAP3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.936

Property	Details
Experiments	24794838, 35271311, 19875381, 21360678, 25036637
Identification Methods	pull down, x-ray crystallography, affinity chromatography technology, isothermal titration calorimetry, tandem affinity purification, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	HSP90~TPR_8
Common GO terms	GO:0005829 - cytosol GO:0050821 - protein stabilization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 665
+	Hs
		174556 HS90A_HUMAN (1-732): 0: 1087: 100.00		OGT1_HUMAN (202-656): 7.67e-29: 125: 11.89
+	Hs
		174561 HS90B_HUMAN (19-732): 0: 1059: 86.13		OGT1_HUMAN (202-656): 7.67e-29: 125: 11.89
+	Hs
		111934 K9JA46_HUMAN (1-732): 0: 1087: 100.00		STIP1_HUMAN (100-594): 6.38e-20: 95.9: 14.23
+	Hs
		431574 HS90A_HUMAN (1-732): 0: 1087: 100.00		STIP1_HUMAN (100-594): 6.38e-20: 95.9: 14.23
+	Hs
		431774 HS90A_HUMAN (1-732): 0: 1087: 100.00		SPAG1_HUMAN (278-622): 2.87e-19: 94.7: 17.14
+	Hs
		297024 HS90A_HUMAN (1-732): 0: 1087: 100.00		TOM70_HUMAN (36-379): 1.61e-15: 82.2: 16.52
+	Hs
		432195 HS90A_HUMAN (1-732): 0: 1087: 100.00		DNJC7_HUMAN (42-289): 2.69e-15: 81.2: 16.11
+	Hs
		111935 K9JA46_HUMAN (1-732): 0: 1087: 100.00		PPP5_HUMAN (131-251): 3.46e-14: 77.4: 32.23
+	Hs
		431681 HS90A_HUMAN (1-732): 0: 1087: 100.00		PPP5_HUMAN (131-251): 3.46e-14: 77.4: 32.23
+	Hs
		432068 HS90A_HUMAN (1-732): 0: 1087: 100.00		TT21A_HUMAN (123-663): 1.32e-13: 76.6: 10.41
+	Mm
		432427 HS90A_MOUSE (1-732): 0: 1083: 97.82		PPP5_MOUSE (131-251): 3.54e-15: 80.5: 33.88
+	Hs
		213451 HS90A_HUMAN (1-732): 0: 1087: 100.00		SGTA_HUMAN (232-399): 1.71e-12: 70.9: 33.33
+	Hs
		437930 HS90B_HUMAN (19-732): 0: 1059: 86.13		STIP1_HUMAN (100-594): 6.38e-20: 95.9: 14.23
+	Hs
		431886 HS90A_HUMAN (1-732): 0: 1087: 100.00		TOM34_HUMAN (52-215): 4.73e-09: 60.4: 15.76
+	Mm
		513680 HS90B_MOUSE (19-732): 0: 1063: 86.98		PPP5_MOUSE (131-251): 3.54e-15: 80.5: 33.88
+	Hs
		297025 HS90B_HUMAN (19-732): 0: 1059: 86.13		TOM70_HUMAN (36-379): 1.61e-15: 82.2: 16.52
+	Hs
		438464 HS90B_HUMAN (19-732): 0: 1059: 86.13		DNJC7_HUMAN (42-289): 2.69e-15: 81.2: 16.11
+	Hs
		438021 HS90B_HUMAN (19-732): 0: 1059: 86.13		PPP5_HUMAN (131-251): 3.46e-14: 77.4: 32.23
+	Hs
		213454 HS90B_HUMAN (19-732): 0: 1059: 86.13		SGTA_HUMAN (232-399): 1.71e-12: 70.9: 33.33
+	Hs
		438201 HS90B_HUMAN (19-732): 0: 1059: 86.13		TOM34_HUMAN (52-215): 4.73e-09: 60.4: 15.76