HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: DYRK4 (Q9NR20)
Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1)
Gene: DYRK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	32707033, 22939624, 25036637
Identification Methods	affinity chromatography technology, pull down, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 520
+	Hs
		438553 HS90B_HUMAN (19-732): 0: 1059: 86.13		DYRK4_HUMAN (1-520): 2.4e-166: 483: 100.00
+	Hs
		431549 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK2_HUMAN (101-411): 1.26e-140: 409: 27.04
+	Hs
		432121 HS90A_HUMAN (1-732): 0: 1087: 100.00		DYRK2_HUMAN (1-462): 1.67e-130: 394: 45.30
+	Hs
		431741 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK3_HUMAN (101-420): 7.13e-134: 392: 26.61
+	Hs
		437908 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK2_HUMAN (101-411): 1.26e-140: 409: 27.04
+	Hs
		432392 HS90A_HUMAN (1-732): 0: 1087: 100.00		DYR1B_HUMAN (1-505): 7.85e-123: 375: 33.33
+	Hs
		431834 HS90A_HUMAN (1-732): 0: 1087: 100.00		DYR1A_HUMAN (4-516): 2.5e-120: 372: 31.94
+	Hs
		438406 HS90B_HUMAN (19-732): 0: 1059: 86.13		DYRK2_HUMAN (1-462): 1.67e-130: 394: 45.30
+	Hs
		414683 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK1_HUMAN (101-405): 3.7e-123: 364: 27.16
+	Hs
		438075 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK3_HUMAN (101-420): 7.13e-134: 392: 26.61
+	Hs
		438648 HS90B_HUMAN (19-732): 0: 1059: 86.13		DYR1B_HUMAN (1-505): 7.85e-123: 375: 33.33
+	Hs
		438155 HS90B_HUMAN (19-732): 0: 1059: 86.13		DYR1A_HUMAN (4-516): 2.5e-120: 372: 31.94
+	Hs
		431656 HS90A_HUMAN (1-732): 0: 1087: 100.00		CLK3_HUMAN (86-405): 7.25e-58: 204: 34.19
+	Hs
		431655 HS90A_HUMAN (1-732): 0: 1087: 100.00		CLK2_HUMAN (81-408): 1.55e-56: 198: 31.73
+	Sp
		383458 HSP90_SCHPO (15-732): 0: 914: 62.08		CDK1_SCHPO (101-404): 1.17e-121: 360: 25.48
+	Sc
		543134 HSC82_YEAST (16-732): 0: 902: 59.39		FUS3_YEAST (93-444): 7.3e-122: 363: 24.93
+	Hs
		437997 HS90B_HUMAN (19-732): 0: 1059: 86.13		CLK3_HUMAN (86-405): 7.25e-58: 204: 34.19
+	Hs
		437996 HS90B_HUMAN (19-732): 0: 1059: 86.13		CLK2_HUMAN (81-408): 1.55e-56: 198: 31.73
+	Sc
		365984 HSP82_YEAST (16-732): 0: 907: 60.08		HOG1_YEAST (99-410): 4.88e-114: 346: 29.34
+	Sc
		539218 HSC82_YEAST (16-732): 0: 902: 59.39		YAK1_YEAST (71-400): 2.93e-72: 247: 38.50