HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: KLHL1 (Q9NR64)
Kelch-like protein 1
Gene: KLHL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	22939624, 25036637
Identification Methods	affinity chromatography technology, luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0043025 - neuronal cell body
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 748
+	Hs
		438555 HS90B_HUMAN (19-732): 0: 1059: 86.13		KLHL1_HUMAN (1-748): 0: 699: 100.00
+	Hs
		432323 HS90A_HUMAN (1-732): 0: 1087: 100.00		KLH13_HUMAN (124-745): 7.37e-173: 512: 27.83
+	Hs
		431841 HS90A_HUMAN (1-732): 0: 1087: 100.00		KEAP1_HUMAN (132-748): 7.72e-170: 504: 33.17
+	Hs
		432115 HS90A_HUMAN (1-732): 0: 1087: 100.00		KLHL6_HUMAN (151-747): 1.97e-166: 495: 25.21
+	Hs
		438582 HS90B_HUMAN (19-732): 0: 1059: 86.13		KLH13_HUMAN (124-745): 7.37e-173: 512: 27.83
+	Hs
		438163 HS90B_HUMAN (19-732): 0: 1059: 86.13		KEAP1_HUMAN (132-748): 7.72e-170: 504: 33.17
+	Hs
		431957 HS90A_HUMAN (1-732): 0: 1087: 100.00		KLH10_HUMAN (179-745): 8.01e-156: 467: 31.83
+	Hs
		438402 HS90B_HUMAN (19-732): 0: 1059: 86.13		KLHL6_HUMAN (151-747): 1.97e-166: 495: 25.21
+	Hs
		432251 HS90A_HUMAN (1-732): 0: 1087: 100.00		KLH25_HUMAN (167-737): 1.55e-152: 458: 26.20
+	Hs
		438266 HS90B_HUMAN (19-732): 0: 1059: 86.13		KLH10_HUMAN (179-745): 8.01e-156: 467: 31.83
+	Hs
		431925 HS90A_HUMAN (1-732): 0: 1087: 100.00		KLH26_HUMAN (174-748): 1.42e-144: 438: 28.48
+	Hs
		438515 HS90B_HUMAN (19-732): 0: 1059: 86.13		KLH25_HUMAN (167-737): 1.55e-152: 458: 26.20
+	Hs
		438236 HS90B_HUMAN (19-732): 0: 1059: 86.13		KLH26_HUMAN (174-748): 1.42e-144: 438: 28.48
+	Hs
		432055 HS90A_HUMAN (1-732): 0: 1087: 100.00		KLH36_HUMAN (537-746): 1.35e-35: 145: 26.82
+	Hs
		438349 HS90B_HUMAN (19-732): 0: 1059: 86.13		KLH36_HUMAN (537-746): 1.35e-35: 145: 26.82
+	Hs
		432143 HS90A_HUMAN (1-732): 0: 1087: 100.00		KLH29_HUMAN (229-602): 3.64e-24: 110: 14.86
+	Hs
		438426 HS90B_HUMAN (19-732): 0: 1059: 86.13		KLH29_HUMAN (229-602): 3.64e-24: 110: 14.86