HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: PIM2 (Q9P1W9)
Serine/threonine-protein kinase pim-2 (EC 2.7.11.1) (Pim-2h)
Gene: PIM2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	32707033, 22939624
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0050821 - protein stabilization
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 311
+	Hs
		432376 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT3_HUMAN (1-307): 4.16e-123: 362: 21.95
+	Hs
		431573 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT2_HUMAN (6-307): 1.14e-122: 361: 22.91
+	Hs
		432019 HS90A_HUMAN (1-732): 0: 1087: 100.00		PIM3_HUMAN (20-294): 2.5e-117: 342: 64.00
+	Hs
		438633 HS90B_HUMAN (19-732): 0: 1059: 86.13		AKT3_HUMAN (1-307): 4.16e-123: 362: 21.95
+	Hs
		437928 HS90B_HUMAN (19-732): 0: 1059: 86.13		AKT2_HUMAN (6-307): 1.14e-122: 361: 22.91
+	Hs
		438576 HS90B_HUMAN (19-732): 0: 1059: 86.13		PIM2_HUMAN (1-311): 6.03e-125: 361: 100.00
+	Hs
		431471 HS90A_HUMAN (1-732): 0: 1087: 100.00		PIM1_HUMAN (6-304): 1.17e-112: 330: 56.29
+	Hs
		438323 HS90B_HUMAN (19-732): 0: 1059: 86.13		PIM3_HUMAN (20-294): 2.5e-117: 342: 64.00
+	Hs
		437837 HS90B_HUMAN (19-732): 0: 1059: 86.13		PIM1_HUMAN (6-304): 1.17e-112: 330: 56.29
+	Sc
		365561 HSP82_YEAST (16-732): 0: 907: 60.08		SNF1_YEAST (19-304): 8.25e-121: 361: 29.35
+	Hs
		538446 ENPL_HUMAN (14-701): 0: 898: 46.78		AKT3_HUMAN (1-307): 4.16e-123: 362: 21.95
+	Zm
		35496 A0A1D6LMW9_MAIZE (4-704): 0: 843: 46.30		A0A1D6QH07_MAIZE (21-304): 2.99e-125: 367: 27.18
+	Hs
		438557 HS90B_HUMAN (19-732): 0: 1059: 86.13		SNRK_HUMAN (32-295): 5.66e-37: 141: 36.88
+	Hs
		1123464 H90B3_HUMAN (19-732): 0: 728: 65.41		AKT3_HUMAN (1-307): 4.16e-123: 362: 21.95
+	Sc
		366998 HSP82_YEAST (16-732): 0: 907: 60.08		PSK2_YEAST (15-287): 4.86e-45: 165: 34.52
+	Sc
		365941 HSP82_YEAST (16-732): 0: 907: 60.08		PSK1_YEAST (38-286): 3.57e-41: 154: 36.58
+	Hs
		1123447 H90B4_HUMAN (30-604): 0: 571: 62.61		AKT3_HUMAN (1-307): 4.16e-123: 362: 21.95