HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: CHRD1 (Q9UHD1)
Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (CHP-1) (Protein morgana)
Gene: CHORDC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.915

Property	Details
Experiments	19875381, 26496610, 23414517, 25036637
Identification Methods	affinity chromatography technology, pull down, two hybrid, tandem affinity purification, anti tag coimmunoprecipitation, two hybrid fragment pooling approach
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CHORD~HSP90
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 332
+	Hs
		111942 K9JA46_HUMAN (1-732): 0: 1087: 100.00		CHRD1_HUMAN (1-332): 4.52e-177: 495: 100.00
+	Mm
		432455 HS90A_MOUSE (1-732): 0: 1083: 97.82		CHRD1_MOUSE (1-328): 5.56e-174: 487: 96.34
+	Hs
		438592 HS90B_HUMAN (19-732): 0: 1059: 86.13		CHRD1_HUMAN (1-332): 4.52e-177: 495: 100.00
+	Mm
		513702 HS90B_MOUSE (19-732): 0: 1063: 86.98		CHRD1_MOUSE (1-328): 5.56e-174: 487: 96.34
+	Hs
		432350 HS90A_HUMAN (1-732): 0: 1087: 100.00		ITBP2_HUMAN (1-326): 6.98e-155: 439: 46.95
+	Mm
		432458 HS90A_MOUSE (1-732): 0: 1083: 97.82		ITBP2_MOUSE (1-326): 6.8e-155: 439: 48.33
+	Mm
		513706 HS90B_MOUSE (19-732): 0: 1063: 86.98		ITBP2_MOUSE (1-326): 6.8e-155: 439: 48.33
+	Hs
		438609 HS90B_HUMAN (19-732): 0: 1059: 86.13		ITBP2_HUMAN (1-326): 6.98e-155: 439: 46.95
+	Dm
		365474 HSP83_DROME (15-732): 0: 1034: 78.41		CHRD1_DROME (4-332): 5.64e-145: 414: 42.18
+	Hs
		432387 HS90A_HUMAN (1-732): 0: 1087: 100.00		SGT1_HUMAN (173-332): 1.99e-46: 162: 18.14
+	Hs
		438644 HS90B_HUMAN (19-732): 0: 1059: 86.13		SGT1_HUMAN (173-332): 1.99e-46: 162: 18.14
+	At
		646596 HS901_ARATH (15-732): 0: 981: 69.49		SGT1A_ARATH (220-332): 3.14e-39: 143: 24.78
+	At
		878286 HS902_ARATH (15-732): 0: 982: 68.24		SGT1B_ARATH (230-331): 1.21e-35: 134: 28.43
+	At
		646597 HS901_ARATH (15-732): 0: 981: 69.49		SGT1B_ARATH (230-331): 1.21e-35: 134: 28.43
+	At
		878285 HS902_ARATH (15-732): 0: 982: 68.24		RAR1_ARATH (157-229): 7.41e-17: 80.3: 36.99
+	At
		646595 HS901_ARATH (15-732): 0: 981: 69.49		RAR1_ARATH (157-229): 7.41e-17: 80.3: 36.99
+	Hs
		538450 ENPL_HUMAN (14-701): 0: 898: 46.78		SGT1_HUMAN (173-332): 1.99e-46: 162: 18.14
+	Sc
		367015 HSP82_YEAST (16-732): 0: 907: 60.08		SGT1_YEAST (213-329): 7.9e-27: 111: 22.14
+	Sc
		544530 HSC82_YEAST (16-732): 0: 902: 59.39		SGT1_YEAST (213-329): 7.9e-27: 111: 22.14