HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: ITBP2 (Q9UKP3)
Integrin beta-1-binding protein 2 (Melusin)
Gene: ITGB1BP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.80	0.709

Property	Details
Experiments	23414517, 18474241
Identification Methods	two hybrid, surface plasmon resonance, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CHORD~HSP90
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 347
+	Mm
		432458 HS90A_MOUSE (1-732): 0: 1083: 97.82		ITBP2_MOUSE (1-317): 1.12e-166: 470: 92.16
+	Hs
		438609 HS90B_HUMAN (19-732): 0: 1059: 86.13		ITBP2_HUMAN (1-347): 4.03e-175: 491: 100.00
+	Mm
		513706 HS90B_MOUSE (19-732): 0: 1063: 86.98		ITBP2_MOUSE (1-317): 1.12e-166: 470: 92.16
+	Hs
		111942 K9JA46_HUMAN (1-732): 0: 1087: 100.00		CHRD1_HUMAN (1-315): 1.21e-145: 416: 46.81
+	Hs
		432333 HS90A_HUMAN (1-732): 0: 1087: 100.00		CHRD1_HUMAN (1-315): 1.21e-145: 416: 46.81
+	Mm
		432455 HS90A_MOUSE (1-732): 0: 1083: 97.82		CHRD1_MOUSE (1-319): 3.05e-143: 409: 45.35
+	Hs
		438592 HS90B_HUMAN (19-732): 0: 1059: 86.13		CHRD1_HUMAN (1-315): 1.21e-145: 416: 46.81
+	Mm
		513702 HS90B_MOUSE (19-732): 0: 1063: 86.98		CHRD1_MOUSE (1-319): 3.05e-143: 409: 45.35
+	Dm
		365474 HSP83_DROME (15-732): 0: 1034: 78.41		CHRD1_DROME (4-339): 9.13e-142: 407: 40.99
+	Hs
		432387 HS90A_HUMAN (1-732): 0: 1087: 100.00		SGT1_HUMAN (103-347): 3.34e-73: 232: 15.27
+	Hs
		438644 HS90B_HUMAN (19-732): 0: 1059: 86.13		SGT1_HUMAN (103-347): 3.34e-73: 232: 15.27
+	At
		878286 HS902_ARATH (15-732): 0: 982: 68.24		SGT1B_ARATH (218-347): 1.15e-44: 158: 22.22
+	At
		646596 HS901_ARATH (15-732): 0: 981: 69.49		SGT1A_ARATH (214-347): 1.23e-44: 158: 21.08
+	At
		646597 HS901_ARATH (15-732): 0: 981: 69.49		SGT1B_ARATH (218-347): 1.15e-44: 158: 22.22
+	Ce
		1090253 HSP90_CAEEL (14-732): 0: 960: 74.83		Q18949_CAEEL (215-347): 4.14e-31: 118: 17.18
+	At
		878285 HS902_ARATH (15-732): 0: 982: 68.24		RAR1_ARATH (149-217): 3.75e-16: 78.3: 40.58
+	At
		646595 HS901_ARATH (15-732): 0: 981: 69.49		RAR1_ARATH (149-217): 3.75e-16: 78.3: 40.58
+	Pf
		83109 Q8IC05_PLAF7 (16-732): 0: 971: 64.23		C0H586_PLAF7 (218-347): 5.16e-12: 66: 13.25
+	Sc
		367015 HSP82_YEAST (16-732): 0: 907: 60.08		SGT1_YEAST (211-339): 4.89e-29: 117: 17.78
+	Sc
		544530 HSC82_YEAST (16-732): 0: 902: 59.39		SGT1_YEAST (211-339): 4.89e-29: 117: 17.78