HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: FBXW2 (Q9UKT8)
F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2) (Protein MD6)
Gene: FBXW2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	22939624, 25036637
Identification Methods	affinity chromatography technology, luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 454
+	Hs
		438612 HS90B_HUMAN (19-732): 0: 1059: 86.13		FBXW2_HUMAN (1-454): 4.52e-104: 318: 100.00
+	Hs
		432379 HS90A_HUMAN (1-732): 0: 1087: 100.00		FBW1A_HUMAN (23-313): 2.4e-60: 208: 17.97
+	Hs
		432132 HS90A_HUMAN (1-732): 0: 1087: 100.00		FBXW7_HUMAN (32-264): 4.84e-57: 201: 21.85
+	Hs
		431630 HS90A_HUMAN (1-732): 0: 1087: 100.00		LIS1_HUMAN (16-256): 1.66e-52: 183: 16.18
+	Hs
		438634 HS90B_HUMAN (19-732): 0: 1059: 86.13		FBW1A_HUMAN (23-313): 2.4e-60: 208: 17.97
+	Hs
		438414 HS90B_HUMAN (19-732): 0: 1059: 86.13		FBXW7_HUMAN (32-264): 4.84e-57: 201: 21.85
+	Hs
		437971 HS90B_HUMAN (19-732): 0: 1059: 86.13		LIS1_HUMAN (16-256): 1.66e-52: 183: 16.18
+	Hs
		432348 HS90A_HUMAN (1-732): 0: 1087: 100.00		FBW1B_HUMAN (31-188): 8.64e-19: 90.6: 13.64
+	Hs
		438606 HS90B_HUMAN (19-732): 0: 1059: 86.13		FBW1B_HUMAN (31-188): 8.64e-19: 90.6: 13.64
+	Hs
		438048 HS90B_HUMAN (19-732): 0: 1059: 86.13		WDR5_HUMAN (353-451): 3.15e-13: 72.5: 6.93
+	Hs
		538344 ENPL_HUMAN (14-701): 0: 898: 46.78		FBXW7_HUMAN (32-264): 4.84e-57: 201: 21.85
+	Hs
		538141 ENPL_HUMAN (14-701): 0: 898: 46.78		LIS1_HUMAN (16-256): 1.66e-52: 183: 16.18
+	Cr
		65491 A8J1U1_CHLRE (12-732): 0: 1003: 68.14		MUT11_CHLRE (179-361): 7.53e-14: 74.7: 29.26
+	Sc
		366295 HSP82_YEAST (16-732): 0: 907: 60.08		MET30_YEAST (212-451): 1.99e-35: 140: 16.73
+	Ca
		483034 HSP90_CANAL (12-732): 0: 914: 60.50		TUP1_CANAL (144-274): 1.22e-13: 74.7: 33.11
+	Sc
		366167 HSP82_YEAST (16-732): 0: 907: 60.08		TAF5_YEAST (163-259): 1.2e-14: 78.2: 39.22
+	Sc
		543602 HSC82_YEAST (16-732): 0: 902: 59.39		TAF5_YEAST (163-259): 1.2e-14: 78.2: 39.22
+	Hs
		538184 ENPL_HUMAN (14-701): 0: 898: 46.78		WDR5_HUMAN (353-451): 3.15e-13: 72.5: 6.93