HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: AURKC (Q9UQB9)
Aurora kinase C (EC 2.7.11.1) (Aurora 3) (Aurora/IPL1-related kinase 3) (ARK-3) (Aurora-related kinase 3) (Aurora/IPL1/Eg2 protein 2) (Serine/threonine-protein kinase 13) (Serine/threonine-protein kinase aurora-C)
Gene: AURKC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	26186194, 28514442, 33961781, 22939624
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 309
+	Hs
		431573 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT2_HUMAN (5-309): 1.4e-135: 394: 30.09
+	Hs
		432376 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT3_HUMAN (15-309): 4.17e-135: 393: 30.84
+	Hs
		160336 HS90A_HUMAN (1-732): 0: 1087: 100.00		AURKA_HUMAN (1-299): 1.69e-135: 391: 64.90
+	Hs
		431572 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT1_HUMAN (5-309): 8.7e-134: 389: 29.47
+	Rn
		812703 HS90A_RAT (1-732): 0: 1085: 97.95		AKT1_RAT (5-309): 7.64e-134: 390: 29.15
+	Hs
		432152 HS90A_HUMAN (1-732): 0: 1087: 100.00		AURKB_HUMAN (3-305): 2.39e-134: 386: 76.39
+	Mm
		432411 HS90A_MOUSE (1-732): 0: 1083: 97.82		AKT1_MOUSE (5-309): 5.82e-134: 390: 29.15
+	Hs
		431511 HS90A_HUMAN (1-732): 0: 1087: 100.00		KAPCA_HUMAN (6-308): 1.57e-133: 384: 29.75
+	Hs
		431538 HS90A_HUMAN (1-732): 0: 1087: 100.00		KAPCB_HUMAN (6-308): 7.39e-133: 382: 28.80
+	Hs
		70435 HS90A_HUMAN (1-732): 0: 1087: 100.00		B2RB89_HUMAN (6-308): 7.39e-133: 382: 28.80
+	Hs
		431537 HS90A_HUMAN (1-732): 0: 1087: 100.00		KAPCG_HUMAN (29-309): 2.77e-132: 381: 31.51
+	Hs
		437928 HS90B_HUMAN (19-732): 0: 1059: 86.13		AKT2_HUMAN (5-309): 1.4e-135: 394: 30.09
+	Mm
		513660 HS90B_MOUSE (19-732): 0: 1063: 86.98		AKT1_MOUSE (5-309): 5.82e-134: 390: 29.15
+	Hs
		160340 HS90B_HUMAN (19-732): 0: 1059: 86.13		AURKA_HUMAN (1-299): 1.69e-135: 391: 64.90
+	Bt
		964601 HS90B_BOVIN (19-732): 0: 1059: 86.28		AKT1_BOVIN (5-309): 1.2e-134: 391: 30.09
+	Hs
		437927 HS90B_HUMAN (19-732): 0: 1059: 86.13		AKT1_HUMAN (5-309): 8.7e-134: 389: 29.47
+	Hs
		438430 HS90B_HUMAN (19-732): 0: 1059: 86.13		AURKB_HUMAN (3-305): 2.39e-134: 386: 76.39
+	Hs
		437870 HS90B_HUMAN (19-732): 0: 1059: 86.13		KAPCA_HUMAN (6-308): 1.57e-133: 384: 29.75
+	Hs
		437900 HS90B_HUMAN (19-732): 0: 1059: 86.13		KAPCB_HUMAN (6-308): 7.39e-133: 382: 28.80
+	Hs
		437898 HS90B_HUMAN (19-732): 0: 1059: 86.13		KAPCG_HUMAN (29-309): 2.77e-132: 381: 31.51