HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: AKT3 (Q9Y243)
RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2)
Gene: AKT3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	28514442, 33961781, 25036637
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016020 - membrane GO:0045793 - positive regulation of cell size
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 479
+	Hs
		431573 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT2_HUMAN (1-479): 0: 561: 75.78
+	Rn
		812703 HS90A_RAT (1-732): 0: 1085: 97.95		AKT1_RAT (1-477): 0: 561: 81.88
+	Hs
		431572 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT1_HUMAN (1-477): 0: 558: 82.29
+	Mm
		432411 HS90A_MOUSE (1-732): 0: 1083: 97.82		AKT1_MOUSE (1-477): 0: 562: 82.08
+	Mm
		513660 HS90B_MOUSE (19-732): 0: 1063: 86.98		AKT1_MOUSE (1-477): 0: 562: 82.08
+	Bt
		964601 HS90B_BOVIN (19-732): 0: 1059: 86.28		AKT1_BOVIN (1-476): 0: 561: 81.84
+	Hs
		431510 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCA_HUMAN (13-476): 6.53e-152: 449: 36.75
+	Hs
		431548 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCL_HUMAN (110-476): 8.45e-151: 447: 41.73
+	Hs
		431752 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCE_HUMAN (52-473): 1.57e-148: 443: 41.41
+	Hs
		408527 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCB_HUMAN (13-476): 3.8e-149: 442: 36.94
+	Hs
		431542 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6B1_HUMAN (89-477): 4.14e-149: 437: 38.68
+	Hs
		431762 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCT_HUMAN (85-479): 8.26e-147: 437: 39.39
+	Hs
		432138 HS90A_HUMAN (1-732): 0: 1087: 100.00		SGK3_HUMAN (61-479): 4.68e-149: 436: 42.35
+	Hs
		432326 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6B2_HUMAN (105-477): 1.09e-148: 434: 40.05
+	Hs
		116956 HS90A_HUMAN (1-732): 0: 1087: 100.00		SGK1_HUMAN (100-477): 4.38e-147: 428: 45.12
+	Hs
		432275 HS90A_HUMAN (1-732): 0: 1087: 100.00		SGK2_HUMAN (117-474): 5.54e-146: 423: 48.07
+	Hs
		116958 HS90B_HUMAN (19-732): 0: 1059: 86.13		SGK1_HUMAN (100-477): 4.38e-147: 428: 45.12
+	Hs
		431876 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6A1_HUMAN (54-459): 5.85e-103: 325: 21.91
+	Hs
		431672 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6A3_HUMAN (146-418): 7.07e-101: 320: 28.52
+	Hs
		431621 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCI_HUMAN (118-473): 3.27e-101: 317: 43.94