HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: SGT1 (Q9Y2Z0)
Protein SGT1 homolog (Protein 40-6-3) (Sgt1) (Suppressor of G2 allele of SKP1 homolog)
Gene: SUGT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.755

Property	Details
Experiments	27249023, 18818696, 19875381, 16501598, 14761955, 17435760, 17466273, 22869522
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, anti tag coimmunoprecipitation, solid phase assay, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 365
+	Hs
		438644 HS90B_HUMAN (19-732): 0: 1059: 86.13		SGT1_HUMAN (1-365): 2.37e-88: 272: 100.00
+	Hs
		213451 HS90A_HUMAN (1-732): 0: 1087: 100.00		SGTA_HUMAN (6-171): 3.42e-40: 146: 20.96
+	Hs
		111935 K9JA46_HUMAN (1-732): 0: 1087: 100.00		PPP5_HUMAN (9-242): 1.39e-38: 145: 14.71
+	Hs
		431681 HS90A_HUMAN (1-732): 0: 1087: 100.00		PPP5_HUMAN (9-242): 1.39e-38: 145: 14.71
+	Mm
		432427 HS90A_MOUSE (1-732): 0: 1083: 97.82		PPP5_MOUSE (9-202): 3.13e-39: 147: 16.58
+	Mm
		513680 HS90B_MOUSE (19-732): 0: 1063: 86.98		PPP5_MOUSE (9-202): 3.13e-39: 147: 16.58
+	Hs
		213454 HS90B_HUMAN (19-732): 0: 1059: 86.13		SGTA_HUMAN (6-171): 3.42e-40: 146: 20.96
+	Hs
		438021 HS90B_HUMAN (19-732): 0: 1059: 86.13		PPP5_HUMAN (9-242): 1.39e-38: 145: 14.71
+	Hs
		432268 HS90A_HUMAN (1-732): 0: 1087: 100.00		RPAP3_HUMAN (3-129): 5.92e-27: 114: 14.17
+	Hs
		431774 HS90A_HUMAN (1-732): 0: 1087: 100.00		SPAG1_HUMAN (2-339): 1.63e-24: 107: 12.50
+	Hs
		174556 HS90A_HUMAN (1-732): 0: 1087: 100.00		OGT1_HUMAN (48-303): 5e-18: 87.6: 9.51
+	Hs
		438533 HS90B_HUMAN (19-732): 0: 1059: 86.13		RPAP3_HUMAN (3-129): 5.92e-27: 114: 14.17
+	Hs
		297024 HS90A_HUMAN (1-732): 0: 1087: 100.00		TOM70_HUMAN (3-221): 1.5e-09: 61.4: 9.29
+	Hs
		174561 HS90B_HUMAN (19-732): 0: 1059: 86.13		OGT1_HUMAN (48-303): 5e-18: 87.6: 9.51
+	At
		99224 HS904_ARATH (15-732): 0: 987: 68.24		OE64M_ARATH (7-124): 2.9e-40: 151: 22.03
+	At
		81971 HS904_ARATH (15-732): 0: 987: 68.24		OEP61_ARATH (10-361): 2.54e-39: 148: 12.53
+	At
		137805 HS904_ARATH (15-732): 0: 987: 68.24		OE64C_ARATH (4-124): 2.18e-38: 146: 21.49
+	At
		81976 HS902_ARATH (15-732): 0: 982: 68.24		OEP61_ARATH (10-361): 2.54e-39: 148: 12.53
+	Hs
		297025 HS90B_HUMAN (19-732): 0: 1059: 86.13		TOM70_HUMAN (3-221): 1.5e-09: 61.4: 9.29
+	Dm
		365481 HSP83_DROME (15-732): 0: 1034: 78.41		Q9VPN5_DROME (1-321): 9.76e-18: 86: 10.98