HitPredict

Interactor 1: HS90A (P07901)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Tumor-specific transplantation 86 kDa antigen) (TSTA)
Gene: Hsp90aa1

Interactor 2: AGO2 (Q8CJG0)
Protein argonaute-2 (Argonaute2) (mAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (Piwi/argonaute family protein meIF2C2) (Protein slicer)
Gene: AGO2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	22918229
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003729 - mRNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 733 Mm			1 860
+	Hs
		432355 HS90A_HUMAN (1-733): 0: 1078: 98.23		AGO2_HUMAN (21-860): 0: 1193: 99.88
+	Mm
		1174807 Q71LX8_MOUSE (19-733): 0: 1053: 86.15		AGO2_MOUSE (1-860): 0: 1216: 100.00
+	Hs
		432356 HS90A_HUMAN (1-733): 0: 1078: 98.23		AGO1_HUMAN (18-860): 0: 1173: 83.16
+	Hs
		438614 HS90B_HUMAN (19-733): 0: 1049: 85.87		AGO2_HUMAN (21-860): 0: 1193: 99.88
+	Hs
		432271 HS90A_HUMAN (1-733): 0: 1078: 98.23		AGO3_HUMAN (17-860): 0: 1155: 80.07
+	Hs
		438615 HS90B_HUMAN (19-733): 0: 1049: 85.87		AGO1_HUMAN (18-860): 0: 1173: 83.16
+	Hs
		432278 HS90A_HUMAN (1-733): 0: 1078: 98.23		AGO4_HUMAN (13-860): 0: 1136: 78.14
+	Hs
		438537 HS90B_HUMAN (19-733): 0: 1049: 85.87		AGO3_HUMAN (17-860): 0: 1155: 80.07
+	Hs
		438545 HS90B_HUMAN (19-733): 0: 1049: 85.87		AGO4_HUMAN (13-860): 0: 1136: 78.14
+	Dm
		365460 HSP83_DROME (15-733): 0: 1023: 77.61		Q32KD4_DROME (4-860): 0: 1129: 72.97
+	At
		138329 HS903_ARATH (15-733): 0: 980: 68.01		AGO1_ARATH (4-859): 0: 1082: 40.93
+	Hs
		1123461 H90B3_HUMAN (19-733): 0: 719: 64.76		AGO3_HUMAN (17-860): 0: 1155: 80.07
+	Hs
		432159 HS90A_HUMAN (1-733): 0: 1078: 98.23		PIWL1_HUMAN (20-827): 0: 751: 21.74
+	Hs
		432088 HS90A_HUMAN (1-733): 0: 1078: 98.23		PIWL2_HUMAN (3-822): 0: 716: 20.94
+	Hs
		432003 HS90A_HUMAN (1-733): 0: 1078: 98.23		PIWL4_HUMAN (20-823): 0: 680: 21.68
+	Dm
		365485 HSP83_DROME (15-733): 0: 1023: 77.61		AGO2_DROME (31-819): 0: 713: 30.84
+	Hs
		1123440 H90B4_HUMAN (30-605): 0: 562: 62.50		AGO3_HUMAN (17-860): 0: 1155: 80.07
+	Dm
		365462 HSP83_DROME (15-733): 0: 1023: 77.61		AGO3_DROME (14-827): 0: 636: 20.67
+	Dm
		365480 HSP83_DROME (15-733): 0: 1023: 77.61		PIWI_DROME (31-811): 0: 579: 22.20
+	Hs
		431946 HS90A_HUMAN (1-733): 0: 1078: 98.23		Q5TA56_HUMAN (27-219): 4.14e-88: 280: 65.84