HitPredict

Interactor 1: HNRPC (P07910)
Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2)
Gene: HNRNPC

Interactor 2: SRSF5 (Q13243)
Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)
Gene: SRSF5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 306 Hs			1 272
+	Hs
		432668 HNRPC_HUMAN (1-306): 1.06e-83: 256: 100.00		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	Hs
		1029154 RALY_HUMAN (2-298): 3.88e-63: 203: 40.19		SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96
+	Hs
		241260 HNRC1_HUMAN (1-306): 2.22e-87: 265: 86.93		PAB4L_HUMAN (5-75): 5.48e-14: 72.8: 24.68
+	Hs
		432527 HNRPC_HUMAN (1-306): 1.06e-83: 256: 100.00		PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56
+	Hs
		432518 HNRPC_HUMAN (1-306): 1.06e-83: 256: 100.00		PAB4L_HUMAN (5-75): 5.48e-14: 72.8: 24.68
+	Hs
		432657 HNRPC_HUMAN (1-306): 1.06e-83: 256: 100.00		SRSF3_HUMAN (4-78): 1.85e-11: 62.8: 47.56
+	Hs
		992863 SRS12_HUMAN (8-190): 2.14e-34: 127: 20.94		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	Hs
		993783 SRS12_HUMAN (8-190): 2.14e-34: 127: 20.94		SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64
+	Hs
		925011 TRA2B_HUMAN (4-164): 1.14e-27: 110: 21.77		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	Hs
		1029020 SRS12_HUMAN (8-190): 2.14e-34: 127: 20.94		SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96
+	Mm
		665756 RALY_MOUSE (3-300): 1.41e-66: 212: 42.19		PABP1_MOUSE (98-189): 1.29e-15: 78.2: 18.56
+	Mm
		192621 TRA2B_MOUSE (4-164): 1.14e-27: 110: 21.77		SRSF5_MOUSE (1-179): 5.42e-54: 177: 100.00
+	Mm
		925167 TRA2B_MOUSE (4-164): 1.14e-27: 110: 21.77		SRSF9_MOUSE (2-211): 1.94e-54: 177: 34.42
+	Hs
		516734 RALY_HUMAN (2-298): 3.88e-63: 203: 40.19		PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56
+	Hs
		952174 RALY_HUMAN (2-298): 3.88e-63: 203: 40.19		SRSF3_HUMAN (4-78): 1.85e-11: 62.8: 47.56
+	Hs
		952060 SRS12_HUMAN (8-190): 2.14e-34: 127: 20.94		SRSF3_HUMAN (4-78): 1.85e-11: 62.8: 47.56
+	Hs
		516451 TRA2B_HUMAN (4-164): 1.14e-27: 110: 21.77		PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56
+	Mm
		857303 TRA2B_MOUSE (4-164): 1.14e-27: 110: 21.77		TIA1_MOUSE (2-101): 7.98e-13: 69.3: 15.69
+	Hs
		925003 TRA2B_HUMAN (4-164): 1.14e-27: 110: 21.77		SRSF3_HUMAN (4-78): 1.85e-11: 62.8: 47.56
+	Mm
		925159 TRA2B_MOUSE (4-164): 1.14e-27: 110: 21.77		SRSF3_MOUSE (4-78): 1.85e-11: 62.8: 47.56