HitPredict

Interactor 1: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Interactor 2: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	31980649, unassigned2173, 22939624
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 543 Hs			1 724
+	Hs
		431433 YES_HUMAN (1-543): 0: 617: 100.00		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		437847 SRC_HUMAN (1-543): 0: 601: 74.22		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431481 SRC_HUMAN (1-543): 0: 601: 74.22		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		411949 FYN_HUMAN (1-543): 0: 582: 72.16		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		411945 FYN_HUMAN (1-543): 0: 582: 72.16		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		437823 FGR_HUMAN (1-542): 0: 562: 67.10		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431451 FGR_HUMAN (1-542): 0: 562: 67.10		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		437817 HCK_HUMAN (1-541): 0: 544: 57.49		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		411556 LCK_HUMAN (83-541): 0: 540: 60.78		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431445 HCK_HUMAN (1-541): 0: 544: 57.49		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		411551 LCK_HUMAN (83-541): 0: 540: 60.78		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Dm
		365472 SRC42_DROME (35-541): 0: 527: 53.79		HSP83_DROME (10-724): 0: 1057: 78.46
+	Hs
		411978 FYN_HUMAN (1-543): 0: 582: 72.16		ENPL_HUMAN (3-693): 0: 917: 46.44
+	Hs
		433379 YES_HUMAN (1-543): 0: 617: 100.00		H90B3_HUMAN (1-724): 0: 815: 75.83
+	Hs
		412223 FYN_HUMAN (1-543): 0: 582: 72.16		H90B3_HUMAN (1-724): 0: 815: 75.83
+	Hs
		454838 FGR_HUMAN (1-542): 0: 562: 67.10		H90B3_HUMAN (1-724): 0: 815: 75.83
+	Hs
		442841 HCK_HUMAN (1-541): 0: 544: 57.49		H90B3_HUMAN (1-724): 0: 815: 75.83
+	Hs
		411751 LCK_HUMAN (83-541): 0: 540: 60.78		H90B3_HUMAN (1-724): 0: 815: 75.83
+	Hs
		433378 YES_HUMAN (1-543): 0: 617: 100.00		H90B4_HUMAN (25-596): 0: 639: 71.85
+	Hs
		412222 FYN_HUMAN (1-543): 0: 582: 72.16		H90B4_HUMAN (25-596): 0: 639: 71.85