HitPredict

Interactor 1: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Interactor 2: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	24728074, 32814769
Identification Methods	pull down, affinity chromatography technology, fluorescence polarization spectroscopy
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005102 - signaling receptor binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019899 - enzyme binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 543 Hs			1 920
+	Hs
		487088 SRC_HUMAN (1-543): 0: 601: 74.22		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		454790 FGR_HUMAN (1-542): 0: 562: 67.10		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		442764 HCK_HUMAN (1-541): 0: 544: 57.49		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		411564 LCK_HUMAN (83-541): 0: 540: 60.78		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		433537 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		487203 ABL2_HUMAN (9-543): 9.27e-166: 503: 37.96		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		487245 BLK_HUMAN (66-538): 5.05e-174: 502: 59.07		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		337320 ABL1_HUMAN (41-543): 5.93e-161: 489: 39.10		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		368834 YES_HUMAN (1-543): 0: 617: 100.00		ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20
+	Hs
		368894 SRC_HUMAN (1-543): 0: 601: 74.22		ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20
+	Rn
		411266 SRC_RAT (1-543): 0: 600: 73.67		ESR1_RAT (378-904): 2.19e-130: 406: 20.94
+	Mm
		403414 SRC_MOUSE (1-543): 0: 598: 73.67		ESR1_MOUSE (378-904): 2.5e-129: 403: 21.30
+	Hs
		433435 YES_HUMAN (1-543): 0: 617: 100.00		ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51
+	Hs
		377057 SRC_HUMAN (1-543): 0: 601: 74.22		GCR_HUMAN (444-920): 1.2e-117: 378: 40.85
+	Hs
		522762 SRC_HUMAN (1-543): 0: 601: 74.22		RXRA_HUMAN (392-902): 7.05e-120: 374: 19.84
+	Hs
		523091 SRC_HUMAN (1-543): 0: 601: 74.22		ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51
+	Hs
		377007 FYN_HUMAN (1-543): 0: 582: 72.16		GCR_HUMAN (444-920): 1.2e-117: 378: 40.85
+	Hs
		414427 SRC_HUMAN (1-543): 0: 601: 74.22		PRGR_HUMAN (469-920): 4.71e-106: 352: 45.73
+	Hs
		487890 SRC_HUMAN (1-543): 0: 601: 74.22		RARA_HUMAN (460-902): 8.57e-110: 348: 19.87
+	Hs
		377006 LCK_HUMAN (83-541): 0: 540: 60.78		GCR_HUMAN (444-920): 1.2e-117: 378: 40.85