HitPredict

Interactor 1: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Interactor 2: EZRI (P15311)
Ezrin (Cytovillin) (Villin-2) (p81)
Gene: EZR

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr
Common GO terms	GO:0005829 - cytosol GO:0005884 - actin filament GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 543 Hs			1 586
+	Hs
		433618 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		RADI_HUMAN (1-586): 7.83e-165: 484: 76.28
+	Hs
		411867 LCK_HUMAN (83-541): 0: 540: 60.78		E41L5_HUMAN (5-586): 7.7e-142: 430: 21.28
+	Hs
		412035 FYN_HUMAN (1-543): 0: 582: 72.16		PTN4_HUMAN (4-480): 1.13e-123: 388: 22.20
+	Hs
		523221 SRC_HUMAN (1-543): 0: 601: 74.22		E41L3_HUMAN (2-466): 2.17e-114: 367: 22.83
+	Hs
		523042 SRC_HUMAN (1-543): 0: 601: 74.22		FRMD5_HUMAN (1-345): 1.1e-114: 354: 25.28
+	Hs
		433617 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		MERL_HUMAN (2-586): 3.18e-146: 436: 44.37
+	Hs
		412416 FYN_HUMAN (1-543): 0: 582: 72.16		E41L3_HUMAN (2-466): 2.17e-114: 367: 22.83
+	Hs
		434020 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		E41L5_HUMAN (5-586): 7.7e-142: 430: 21.28
+	Hs
		411855 LCK_HUMAN (83-541): 0: 540: 60.78		E41L1_HUMAN (3-524): 3.54e-119: 375: 23.06
+	Hs
		411904 LCK_HUMAN (83-541): 0: 540: 60.78		FARP1_HUMAN (3-549): 1.97e-117: 375: 19.07
+	Hs
		433541 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		EPB41_HUMAN (3-553): 9.55e-129: 400: 22.99
+	Hs
		411899 LCK_HUMAN (83-541): 0: 540: 60.78		E41L3_HUMAN (2-466): 2.17e-114: 367: 22.83
+	Hs
		434004 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		E41LB_HUMAN (4-554): 6.81e-121: 380: 17.59
+	Hs
		434008 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		E41L1_HUMAN (3-524): 3.54e-119: 375: 23.06
+	Hs
		434097 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		FARP1_HUMAN (3-549): 1.97e-117: 375: 19.07
+	Hs
		204599 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		E41L2_HUMAN (2-577): 1.05e-117: 374: 19.70
+	Hs
		434091 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		E41L3_HUMAN (2-466): 2.17e-114: 367: 22.83
+	Hs
		299230 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		FARP2_HUMAN (2-548): 8.98e-114: 365: 19.42
+	Hs
		337358 ABL1_HUMAN (41-543): 5.93e-161: 489: 39.10		PTN4_HUMAN (4-480): 1.13e-123: 388: 22.20
+	Hs
		337601 ABL1_HUMAN (41-543): 5.93e-161: 489: 39.10		E41L3_HUMAN (2-466): 2.17e-114: 367: 22.83