HitPredict

Interactor 1: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Interactor 2: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	26186194
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019899 - enzyme binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 543 Hs			1 317
+	Hs
		522789 SRC_HUMAN (1-543): 0: 601: 74.22		IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00
+	Hs
		337352 ABL1_HUMAN (41-543): 5.93e-161: 489: 39.10		IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00
+	Hs
		337406 ABL1_HUMAN (41-543): 5.93e-161: 489: 39.10		DAPK1_HUMAN (27-317): 1.12e-62: 216: 17.11
+	Hs
		412002 FYN_HUMAN (1-543): 0: 582: 72.16		BCL3_HUMAN (26-234): 3e-29: 118: 24.76
+	Hs
		433701 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		ANK2_HUMAN (118-315): 9.61e-41: 153: 23.50
+	Hs
		411697 LCK_HUMAN (83-541): 0: 540: 60.78		ANK3_HUMAN (1-130): 1.86e-30: 123: 10.77
+	Hs
		411590 LCK_HUMAN (83-541): 0: 540: 60.78		BCL3_HUMAN (26-234): 3e-29: 118: 24.76
+	Hs
		433730 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		ANK3_HUMAN (1-130): 1.86e-30: 123: 10.77
+	Dm
		337696 SRC64_DROME (1-542): 1.76e-173: 503: 46.57		TNKS_DROME (115-314): 1.05e-33: 133: 19.73
+	Hs
		411885 LCK_HUMAN (83-541): 0: 540: 60.78		KDIS_HUMAN (225-314): 1.26e-20: 94.5: 13.33
+	Hs
		434071 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		KDIS_HUMAN (225-314): 1.26e-20: 94.5: 13.33
+	Hs
		434072 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		ANR50_HUMAN (2-66): 2.02e-09: 60.6: 4.62
+	Hs
		665439 EPHA3_HUMAN (3-535): 2.01e-156: 473: 25.84		KDIS_HUMAN (225-314): 1.26e-20: 94.5: 13.33