HitPredict

Interactor 1: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Interactor 2: SRC8 (Q14247)
Src substrate cortactin (Amplaxin) (Oncogene EMS1)
Gene: CTTN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16631103
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0005884 - actin filament GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 543 Hs			1 550
+	Hs
		522981 SRC_HUMAN (1-543): 0: 601: 74.22		SRC8_HUMAN (1-550): 0: 559: 100.00
+	Mm
		639446 LYN_MOUSE (1-541): 1.19e-179: 517: 53.14		SRC8_MOUSE (1-550): 0: 548: 92.18
+	Mm
		763381 FYN_MOUSE (1-543): 0: 582: 71.98		HCLS1_MOUSE (1-549): 1.3e-140: 417: 39.71
+	Hs
		454795 FGR_HUMAN (1-542): 0: 562: 67.10		HCLS1_HUMAN (1-550): 7.82e-141: 417: 37.50
+	Mm
		411921 LCK_MOUSE (83-541): 0: 542: 60.78		HCLS1_MOUSE (1-549): 1.3e-140: 417: 39.71
+	Mm
		639438 LYN_MOUSE (1-541): 1.19e-179: 517: 53.14		HCLS1_MOUSE (1-549): 1.3e-140: 417: 39.71
+	Hs
		433551 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		HCLS1_HUMAN (1-550): 7.82e-141: 417: 37.50
+	Hs
		522758 SRC_HUMAN (1-543): 0: 601: 74.22		PLCG1_HUMAN (212-549): 1.13e-35: 144: 16.48
+	Hs
		412000 FYN_HUMAN (1-543): 0: 582: 72.16		PLCG1_HUMAN (212-549): 1.13e-35: 144: 16.48
+	Hs
		412328 FYN_HUMAN (1-543): 0: 582: 72.16		SH3G2_HUMAN (365-549): 1.87e-31: 126: 17.28
+	Hs
		412329 FYN_HUMAN (1-543): 0: 582: 72.16		SH3G3_HUMAN (365-549): 5.45e-31: 125: 18.82
+	Hs
		433354 YES_HUMAN (1-543): 0: 617: 100.00		LASP1_HUMAN (358-547): 4.29e-13: 71.4: 22.93
+	Hs
		433732 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		MYO1E_HUMAN (165-549): 3.1e-44: 170: 15.01
+	Hs
		411715 LCK_HUMAN (83-541): 0: 540: 60.78		SPTN1_HUMAN (213-549): 1.51e-33: 138: 14.12
+	Hs
		433753 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		SPTN1_HUMAN (213-549): 1.51e-33: 138: 14.12
+	Hs
		580953 ABL2_HUMAN (9-543): 9.27e-166: 503: 37.96		PLCG1_HUMAN (212-549): 1.13e-35: 144: 16.48
+	Mm
		639449 LYN_MOUSE (1-541): 1.19e-179: 517: 53.14		DBNL_MOUSE (335-550): 1.4e-31: 128: 29.46
+	Hs
		433781 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		ITSN1_HUMAN (165-548): 1.66e-14: 78.9: 11.99
+	Hs
		235483 ABL2_HUMAN (9-543): 9.27e-166: 503: 37.96		VINEX_HUMAN (254-546): 4.43e-13: 73.9: 13.51
+	Hs
		298959 ABL2_HUMAN (9-543): 9.27e-166: 503: 37.96		SRBS2_HUMAN (447-549): 1.56e-11: 69.2: 21.91