HitPredict

Interactor 1: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Interactor 2: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0004713 - protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 543 Hs			1 1308
+	Hs
		522997 SRC_HUMAN (1-543): 0: 601: 74.22		ERBB4_HUMAN (1-1308): 0: 1406: 100.00
+	Hs
		433253 YES_HUMAN (1-543): 0: 617: 100.00		ERBB3_HUMAN (1-1258): 0: 1094: 47.33
+	Hs
		383538 YES_HUMAN (1-543): 0: 617: 100.00		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Hs
		522774 SRC_HUMAN (1-543): 0: 601: 74.22		ERBB3_HUMAN (1-1258): 0: 1094: 47.33
+	Hs
		383570 SRC_HUMAN (1-543): 0: 601: 74.22		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Hs
		337789 YES_HUMAN (1-543): 0: 617: 100.00		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		337850 SRC_HUMAN (1-543): 0: 601: 74.22		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		522984 SRC_HUMAN (1-543): 0: 601: 74.22		FAK2_HUMAN (676-1190): 1.28e-126: 418: 26.79
+	Hs
		337329 SRC_HUMAN (1-543): 0: 601: 74.22		ABL1_HUMAN (693-1305): 3.03e-121: 406: 25.00
+	Hs
		433265 YES_HUMAN (1-543): 0: 617: 100.00		EPHB2_HUMAN (647-987): 4.64e-116: 390: 34.45
+	Hs
		522803 SRC_HUMAN (1-543): 0: 601: 74.22		EPHB2_HUMAN (647-987): 4.64e-116: 390: 34.45
+	Hs
		433329 YES_HUMAN (1-543): 0: 617: 100.00		FAK1_HUMAN (703-997): 6.55e-59: 223: 39.53
+	Hs
		111147 YES_HUMAN (1-543): 0: 617: 100.00		I6L996_HUMAN (703-997): 2.55e-60: 222: 39.53
+	Hs
		433331 YES_HUMAN (1-543): 0: 617: 100.00		ACK1_HUMAN (697-970): 1.51e-54: 209: 40.43
+	Hs
		522927 SRC_HUMAN (1-543): 0: 601: 74.22		FAK1_HUMAN (703-997): 6.55e-59: 223: 39.53
+	Gg
		337665 SRC_CHICK (1-543): 0: 602: 73.67		FAK1_CHICK (703-1004): 7.2e-58: 220: 37.42
+	Hs
		522840 SRC_HUMAN (1-543): 0: 601: 74.22		ABL2_HUMAN (713-980): 1.37e-55: 214: 42.59
+	Hs
		522936 SRC_HUMAN (1-543): 0: 601: 74.22		ACK1_HUMAN (697-970): 1.51e-54: 209: 40.43
+	Hs
		522802 SRC_HUMAN (1-543): 0: 601: 74.22		EPHA3_HUMAN (705-987): 6.17e-54: 207: 39.10
+	Hs
		435518 SRC_HUMAN (1-543): 0: 601: 74.22		IGF1R_HUMAN (333-691): 3.78e-32: 138: 18.11