HitPredict

Interactor 1: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Interactor 2: PIM3 (Q86V86)
Serine/threonine-protein kinase pim-3 (EC 2.7.11.1)
Gene: PIM3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 543 Hs			1 326
+	Hs
		523045 SRC_HUMAN (1-543): 0: 601: 74.22		PIM3_HUMAN (1-326): 5.96e-126: 365: 100.00
+	Hs
		522810 SRC_HUMAN (1-543): 0: 601: 74.22		AKT1_HUMAN (11-323): 2.69e-123: 363: 23.03
+	Mm
		403418 SRC_MOUSE (1-543): 0: 598: 73.67		AKT1_MOUSE (11-323): 5.31e-124: 365: 22.73
+	Mm
		397197 SRC_MOUSE (1-543): 0: 598: 73.67		KAPCA_MOUSE (30-325): 3.34e-122: 356: 23.87
+	Hs
		412247 FYN_HUMAN (1-543): 0: 582: 72.16		PIM3_HUMAN (1-326): 5.96e-126: 365: 100.00
+	Hs
		412046 FYN_HUMAN (1-543): 0: 582: 72.16		AKT1_HUMAN (11-323): 2.69e-123: 363: 23.03
+	Hs
		411994 FYN_HUMAN (1-543): 0: 582: 72.16		KAPCA_HUMAN (28-325): 2.63e-123: 359: 24.36
+	Hs
		412014 FYN_HUMAN (1-543): 0: 582: 72.16		KAPCB_HUMAN (28-325): 3.41e-122: 356: 24.36
+	Hs
		411606 LCK_HUMAN (83-541): 0: 540: 60.78		MARK3_HUMAN (4-324): 3.45e-124: 374: 25.00
+	Hs
		411778 LCK_HUMAN (83-541): 0: 540: 60.78		MARK2_HUMAN (12-318): 3.13e-123: 373: 27.30
+	Hs
		433589 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		MARK3_HUMAN (4-324): 3.45e-124: 374: 25.00
+	Hs
		433850 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		MARK2_HUMAN (12-318): 3.13e-123: 373: 27.30
+	Hs
		433609 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		AKT2_HUMAN (11-323): 4.07e-126: 371: 23.71
+	Hs
		433864 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		PIM3_HUMAN (1-326): 5.96e-126: 365: 100.00
+	Hs
		789125 FRK_HUMAN (71-535): 1.11e-172: 499: 48.25		PIM3_HUMAN (1-326): 5.96e-126: 365: 100.00
+	Hs
		433949 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		MARK4_HUMAN (31-293): 1.31e-110: 339: 28.52
+	Hs
		681838 PTK6_HUMAN (88-536): 9.35e-164: 474: 42.73		AKT1_HUMAN (11-323): 2.69e-123: 363: 23.03
+	Hs
		433470 YES_HUMAN (1-543): 0: 617: 100.00		SIK2_HUMAN (40-294): 8.16e-34: 133: 32.82
+	Hs
		229915 FYN_HUMAN (1-543): 0: 582: 72.16		NUAK1_HUMAN (33-293): 5.1e-34: 133: 31.23