HitPredict

Interactor 1: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Interactor 2: SHIP1 (Q92835)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN)
Gene: INPP5D

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	35044719
Identification Methods	phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 543 Hs			1 1189
+	Mm
		403460 SRC_MOUSE (1-543): 0: 598: 73.67		SHIP1_MOUSE (1-1189): 0: 858: 87.11
+	Hs
		442867 HCK_HUMAN (1-541): 0: 544: 57.49		SHIP1_HUMAN (1-1189): 0: 883: 100.00
+	Hs
		433931 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		SHIP1_HUMAN (1-1189): 0: 883: 100.00
+	Mm
		337638 ABL1_MOUSE (41-543): 2.47e-161: 490: 39.10		SHIP1_MOUSE (1-1189): 0: 858: 87.11
+	Hs
		176351 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		SHIP2_HUMAN (3-1169): 0: 697: 39.77
+	Hs
		176332 ABL1_HUMAN (41-543): 5.93e-161: 489: 39.10		SHIP2_HUMAN (3-1169): 0: 697: 39.77
+	Hs
		69199 A9UF07_HUMAN (55-543): 2.24e-155: 487: 40.00		SHIP2_HUMAN (3-1169): 0: 697: 39.77
+	Hs
		166024 FYN_HUMAN (1-543): 0: 582: 72.16		SYNJ2_HUMAN (218-1188): 6.78e-172: 549: 18.76
+	Hs
		433324 YES_HUMAN (1-543): 0: 617: 100.00		OCRL_HUMAN (269-781): 8.78e-142: 453: 23.43
+	Hs
		522919 SRC_HUMAN (1-543): 0: 601: 74.22		OCRL_HUMAN (269-781): 8.78e-142: 453: 23.43
+	Hs
		166023 ABL1_HUMAN (41-543): 5.93e-161: 489: 39.10		SYNJ2_HUMAN (218-1188): 6.78e-172: 549: 18.76
+	Hs
		412137 FYN_HUMAN (1-543): 0: 582: 72.16		OCRL_HUMAN (269-781): 8.78e-142: 453: 23.43
+	Hs
		411678 LCK_HUMAN (83-541): 0: 540: 60.78		OCRL_HUMAN (269-781): 8.78e-142: 453: 23.43
+	Ce
		105275 SRC1_CAEEL (1-541): 2.11e-169: 492: 47.02		SYNJ_CAEEL (193-963): 7.71e-150: 481: 17.20
+	Hs
		243126 SRC_HUMAN (1-543): 0: 601: 74.22		SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26
+	Mm
		292397 FYN_MOUSE (1-543): 0: 582: 71.98		SH21A_MOUSE (7-116): 3.21e-22: 95.1: 44.55
+	Hs
		243121 FYN_HUMAN (1-543): 0: 582: 72.16		SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26
+	Hs
		243120 LCK_HUMAN (83-541): 0: 540: 60.78		SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26
+	Hs
		203198 LCK_HUMAN (83-541): 0: 540: 60.78		SYNJ1_HUMAN (720-1118): 4.38e-12: 73.1: 10.05
+	Hs
		243122 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26