HitPredict

Interactor 1: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Interactor 2: TRPV4 (Q9HBA0)
Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC)
Gene: TRPV4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12538589
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 543 Hs			1 871
+	Hs
		523156 SRC_HUMAN (1-543): 0: 601: 74.22		TRPV4_HUMAN (1-871): 0: 777: 100.00
+	Hs
		412360 FYN_HUMAN (1-543): 0: 582: 72.16		TRPV4_HUMAN (1-871): 0: 777: 100.00
+	Hs
		442885 HCK_HUMAN (1-541): 0: 544: 57.49		TRPV4_HUMAN (1-871): 0: 777: 100.00
+	Hs
		411863 LCK_HUMAN (83-541): 0: 540: 60.78		TRPV4_HUMAN (1-871): 0: 777: 100.00
+	Hs
		434017 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		TRPV4_HUMAN (1-871): 0: 777: 100.00
+	Mm
		403442 SRC_MOUSE (1-543): 0: 598: 73.67		TRPC6_MOUSE (64-851): 1.64e-107: 354: 13.25
+	Hs
		523215 SRC_HUMAN (1-543): 0: 601: 74.22		TRPC6_HUMAN (90-851): 5.77e-103: 342: 13.16
+	Hs
		412414 FYN_HUMAN (1-543): 0: 582: 72.16		TRPC6_HUMAN (90-851): 5.77e-103: 342: 13.16
+	Mm
		403465 SRC_MOUSE (1-543): 0: 598: 73.67		TRPC5_MOUSE (183-831): 4.31e-88: 303: 13.56
+	Mm
		403467 SRC_MOUSE (1-543): 0: 598: 73.67		TRPC2_MOUSE (138-778): 2.02e-85: 298: 14.81
+	Mm
		403462 SRC_MOUSE (1-543): 0: 598: 73.67		TRPC4_MOUSE (211-843): 1.77e-83: 290: 13.42