HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	24728074, 34079125
Identification Methods	pull down, proximity labelling technology, fluorescence polarization spectroscopy
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0004713 - protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0009986 - cell surface
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 512 Hs			1 1390
+	Hs
		441403 HCK_HUMAN (1-512): 0: 595: 70.70		MET_HUMAN (1-1390): 0: 1283: 100.00
+	Hs
		411558 LCK_HUMAN (1-512): 0: 582: 63.62		MET_HUMAN (1-1390): 0: 1283: 100.00
+	Hs
		441415 SRC_HUMAN (1-510): 0: 580: 51.97		MET_HUMAN (1-1390): 0: 1283: 100.00
+	Hs
		433602 LYN_HUMAN (1-512): 0: 611: 100.00		EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13
+	Hs
		433662 LYN_HUMAN (1-512): 0: 611: 100.00		EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20
+	Hs
		522802 SRC_HUMAN (1-510): 0: 580: 51.97		EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13
+	Hs
		433772 LYN_HUMAN (1-512): 0: 611: 100.00		EPHA7_HUMAN (587-1389): 6.03e-156: 498: 18.53
+	Hs
		433573 LYN_HUMAN (1-512): 0: 611: 100.00		FGFR2_HUMAN (1029-1379): 3.01e-105: 355: 33.15
+	Hs
		522773 SRC_HUMAN (1-510): 0: 580: 51.97		FGFR2_HUMAN (1029-1379): 3.01e-105: 355: 33.15
+	Hs
		165143 LYN_HUMAN (1-512): 0: 611: 100.00		PLXB2_HUMAN (365-1012): 1.26e-58: 225: 16.57
+	Hs
		433523 LYN_HUMAN (1-512): 0: 611: 100.00		IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16
+	Hs
		411613 LCK_HUMAN (1-512): 0: 582: 63.62		UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90
+	Hs
		434064 LYN_HUMAN (1-512): 0: 611: 100.00		PLXA1_HUMAN (461-1020): 8.14e-54: 209: 20.36
+	Hs
		433770 LYN_HUMAN (1-512): 0: 611: 100.00		ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75
+	Hs
		442833 HCK_HUMAN (1-512): 0: 595: 70.70		ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75
+	Hs
		435518 SRC_HUMAN (1-510): 0: 580: 51.97		IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16
+	Hs
		337315 HCK_HUMAN (1-512): 0: 595: 70.70		ABL1_HUMAN (1084-1341): 1.06e-51: 201: 41.38
+	Hs
		411729 LCK_HUMAN (1-512): 0: 582: 63.62		ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75
+	Hs
		337329 SRC_HUMAN (1-510): 0: 580: 51.97		ABL1_HUMAN (1084-1341): 1.06e-51: 201: 41.38
+	Hs
		411626 LCK_HUMAN (1-512): 0: 582: 63.62		CSK_HUMAN (1082-1340): 5.46e-52: 192: 40.77