HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: CD22 (P20273)
B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22)
Gene: CD22

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

Property	Details
Experiments	10748054, 10228003, 8647200
Identification Methods	enzymatic study, affinity chromatography technology, affinity technology, coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005102 - signaling receptor binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0009986 - cell surface GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 512 Hs			1 847
+	Hs
		433742 LYN_HUMAN (1-512): 0: 611: 100.00		PTK7_HUMAN (17-789): 6.28e-108: 358: 15.04
+	Hs
		433947 LYN_HUMAN (1-512): 0: 611: 100.00		KIRR1_HUMAN (3-500): 6.45e-54: 202: 20.38
+	Hs
		235231 FYN_HUMAN (1-510): 0: 576: 54.12		NPHN_HUMAN (12-522): 3.31e-38: 156: 19.07
+	Hs
		235232 YES_HUMAN (1-510): 0: 572: 54.26		NPHN_HUMAN (12-522): 3.31e-38: 156: 19.07
+	Hs
		412004 FYN_HUMAN (1-510): 0: 576: 54.12		MAG_HUMAN (153-541): 1.61e-32: 136: 20.28
+	Hs
		433249 YES_HUMAN (1-510): 0: 572: 54.26		VCAM1_HUMAN (420-769): 2.41e-30: 130: 17.62
+	Hs
		433804 LYN_HUMAN (1-512): 0: 611: 100.00		SDK2_HUMAN (119-834): 2.36e-13: 76.6: 10.52
+	Dm
		337715 SRC64_DROME (20-510): 3.4e-178: 513: 43.91		Q9W4T9_DROME (250-675): 2e-15: 82.8: 24.19