HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005524 - ATP binding GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation GO:0018108 - peptidyl-tyrosine phosphorylation and 1 others more... GO:0046777 - protein autophosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 512 Hs			1 802
+	Hs
		433573 LYN_HUMAN (1-512): 0: 611: 100.00		FGFR2_HUMAN (4-797): 0: 737: 56.44
+	Hs
		522773 SRC_HUMAN (1-510): 0: 580: 51.97		FGFR2_HUMAN (4-797): 0: 737: 56.44
+	Hs
		507818 SRC_HUMAN (1-510): 0: 580: 51.97		FGFR1_HUMAN (3-794): 0: 706: 54.76
+	Hs
		433602 LYN_HUMAN (1-512): 0: 611: 100.00		EPHA3_HUMAN (4-778): 0: 595: 18.34
+	Hs
		433772 LYN_HUMAN (1-512): 0: 611: 100.00		EPHA7_HUMAN (4-781): 0: 584: 19.90
+	Hs
		433662 LYN_HUMAN (1-512): 0: 611: 100.00		EPHA4_HUMAN (4-776): 0: 582: 19.47
+	Hs
		433601 LYN_HUMAN (1-512): 0: 611: 100.00		EPHA2_HUMAN (4-789): 0: 573: 19.58
+	Hs
		411611 LCK_HUMAN (1-512): 0: 582: 63.62		EPHA2_HUMAN (4-789): 0: 573: 19.58
+	Hs
		433661 LYN_HUMAN (1-512): 0: 611: 100.00		EPHB3_HUMAN (4-778): 2.87e-175: 532: 17.83
+	Hs
		384114 LYN_HUMAN (1-512): 0: 611: 100.00		NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53
+	Hs
		384184 SRC_HUMAN (1-510): 0: 580: 51.97		NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53
+	Hs
		411613 LCK_HUMAN (1-512): 0: 582: 63.62		UFO_HUMAN (5-793): 5.98e-159: 486: 22.59
+	Hs
		434125 SRC_HUMAN (1-510): 0: 580: 51.97		RET_HUMAN (221-802): 2.33e-148: 465: 34.72
+	Hs
		433539 LYN_HUMAN (1-512): 0: 611: 100.00		KIT_HUMAN (454-785): 1.44e-68: 246: 37.62
+	Hs
		442765 HCK_HUMAN (1-512): 0: 595: 70.70		KIT_HUMAN (454-785): 1.44e-68: 246: 37.62
+	Hs
		411567 LCK_HUMAN (1-512): 0: 582: 63.62		KIT_HUMAN (454-785): 1.44e-68: 246: 37.62
+	Hs
		499222 SRC_HUMAN (1-510): 0: 580: 51.97		KIT_HUMAN (454-785): 1.44e-68: 246: 37.62
+	Hs
		433742 LYN_HUMAN (1-512): 0: 611: 100.00		PTK7_HUMAN (153-424): 7.29e-20: 97.1: 16.36
+	Hs
		426976 LYN_HUMAN (1-512): 0: 611: 100.00		CSF1R_HUMAN (33-405): 1.65e-12: 73.2: 15.41
+	Hs
		426981 SRC_HUMAN (1-510): 0: 580: 51.97		CSF1R_HUMAN (33-405): 1.65e-12: 73.2: 15.41