HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: FCG2B (P31994)
Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)
Gene: FCGR2B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.585

Property	Details
Experiments	9232445, 10382761
Identification Methods	pull down
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030889 - negative regulation of B cell proliferation GO:0050777 - negative regulation of immune response
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 512 Hs			1 310
+	Hs
		522811 SRC_HUMAN (1-510): 0: 580: 51.97		FCG2B_HUMAN (1-310): 7.03e-74: 231: 100.00
+	Hs
		412047 FYN_HUMAN (1-510): 0: 576: 54.12		FCG2B_HUMAN (1-310): 7.03e-74: 231: 100.00
+	Hs
		433545 LYN_HUMAN (1-512): 0: 611: 100.00		FCG2A_HUMAN (38-310): 3.57e-58: 191: 73.29
+	Hs
		522812 SRC_HUMAN (1-510): 0: 580: 51.97		FCG2C_HUMAN (1-310): 1.99e-62: 202: 83.92
+	Hs
		412048 FYN_HUMAN (1-510): 0: 576: 54.12		FCG2C_HUMAN (1-310): 1.99e-62: 202: 83.92
+	Hs
		434111 LYN_HUMAN (1-512): 0: 611: 100.00		ROBO1_HUMAN (2-252): 1.27e-43: 161: 14.44
+	Hs
		411560 LCK_HUMAN (1-512): 0: 582: 63.62		FCG3A_HUMAN (38-272): 1.15e-50: 169: 36.93
+	Mm
		639452 LYN_MOUSE (1-512): 0: 612: 96.09		FCRL5_MOUSE (5-253): 1.79e-34: 133: 19.33
+	Hs
		434081 LYN_HUMAN (1-512): 0: 611: 100.00		TUTLB_HUMAN (2-304): 6.34e-33: 130: 15.73
+	Hs
		434019 LYN_HUMAN (1-512): 0: 611: 100.00		ROBO2_HUMAN (2-125): 1.59e-22: 99.8: 15.91
+	Hs
		523211 SRC_HUMAN (1-510): 0: 580: 51.97		TUTLB_HUMAN (2-304): 6.34e-33: 130: 15.73
+	Hs
		433507 YES_HUMAN (1-510): 0: 572: 54.26		TUTLB_HUMAN (2-304): 6.34e-33: 130: 15.73
+	Mm
		435878 HCK_MOUSE (1-512): 0: 592: 69.92		FCGR1_MOUSE (5-304): 1.63e-24: 104: 16.09
+	Hs
		442771 HCK_HUMAN (1-512): 0: 595: 70.70		FCGR1_HUMAN (5-285): 9.76e-21: 92.9: 12.25
+	Hs
		433569 LYN_HUMAN (1-512): 0: 611: 100.00		CD22_HUMAN (92-310): 1.59e-09: 60.9: 13.33
+	Hs
		523003 SRC_HUMAN (1-510): 0: 580: 51.97		MYLK_HUMAN (49-129): 7.38e-12: 68.3: 13.83
+	Hs
		519400 SRC_HUMAN (1-510): 0: 580: 51.97		FCERA_HUMAN (2-133): 1.62e-12: 68.2: 16.06
+	Dm
		219802 ABL_DROME (3-508): 3.3e-170: 523: 36.36		O44924_DROME (2-167): 3.27e-25: 107: 16.11
+	Hs
		789014 TEC_HUMAN (35-505): 1.09e-160: 472: 35.48		TUTLB_HUMAN (2-304): 6.34e-33: 130: 15.73