HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 512 Hs			1 1824
+	Hs
		522873 SRC_HUMAN (1-510): 0: 580: 51.97		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		433300 YES_HUMAN (1-510): 0: 572: 54.26		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		433768 LYN_HUMAN (1-512): 0: 611: 100.00		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		442832 HCK_HUMAN (1-512): 0: 595: 70.70		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		411726 LCK_HUMAN (1-512): 0: 582: 63.62		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		522995 SRC_HUMAN (1-510): 0: 580: 51.97		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		412200 FYN_HUMAN (1-510): 0: 576: 54.12		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		433356 YES_HUMAN (1-510): 0: 572: 54.26		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		454833 FGR_HUMAN (1-510): 0: 562: 53.61		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		442887 HCK_HUMAN (1-512): 0: 595: 70.70		GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72
+	Hs
		433758 LYN_HUMAN (1-512): 0: 611: 100.00		SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85
+	Hs
		434073 LYN_HUMAN (1-512): 0: 611: 100.00		NEB1_HUMAN (1002-1092): 1.04e-19: 98.7: 40.00
+	Hs
		433729 LYN_HUMAN (1-512): 0: 611: 100.00		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Mm
		403445 SRC_MOUSE (1-510): 0: 577: 52.07		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Hs
		412128 FYN_HUMAN (1-510): 0: 576: 54.12		DLG4_HUMAN (1002-1238): 1.07e-27: 123: 17.51
+	Hs
		986376 BTK_HUMAN (2-505): 1.48e-156: 462: 33.86		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		411718 LCK_HUMAN (1-512): 0: 582: 63.62		SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85
+	Hs
		411696 LCK_HUMAN (1-512): 0: 582: 63.62		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Hs
		411905 LCK_HUMAN (1-512): 0: 582: 63.62		MYO5A_HUMAN (1369-1800): 2.36e-11: 71.5: 10.74
+	Dm
		113065 ABL_DROME (3-508): 3.3e-170: 523: 36.36		M9NFI9_DROME (1002-1092): 6.19e-22: 106: 38.95