HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: DYST (Q03001)
Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein)
Gene: DST

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005178 - integrin binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 512 Hs			1 7570
+	Hs
		411682 LCK_HUMAN (1-512): 0: 582: 63.62		DYST_HUMAN (1-7570): 0: 2600: 100.00
+	Hs
		433543 LYN_HUMAN (1-512): 0: 611: 100.00		DMD_HUMAN (383-1643): 8.98e-27: 124: 11.75
+	Hs
		433700 LYN_HUMAN (1-512): 0: 611: 100.00		SPTB2_HUMAN (5709-7570): 7.99e-22: 108: 12.95
+	Hs
		434078 LYN_HUMAN (1-512): 0: 611: 100.00		MACF1_HUMAN (351-1936): 4.95e-21: 105: 11.05
+	Hs
		164555 LYN_HUMAN (1-512): 0: 611: 100.00		SPTN2_HUMAN (5708-7163): 4.91e-17: 92.5: 14.91
+	Hs
		521454 SRC_HUMAN (1-510): 0: 580: 51.97		ACTN1_HUMAN (3770-4283): 1.06e-26: 123: 10.00
+	Hs
		433640 LYN_HUMAN (1-512): 0: 611: 100.00		UTRN_HUMAN (264-1530): 1.26e-14: 84.8: 9.65
+	Hs
		433753 LYN_HUMAN (1-512): 0: 611: 100.00		SPTN1_HUMAN (269-874): 2.44e-13: 80.3: 13.42
+	Hs
		411676 LCK_HUMAN (1-512): 0: 582: 63.62		SPTB2_HUMAN (5709-7570): 7.99e-22: 108: 12.95
+	Hs
		411889 LCK_HUMAN (1-512): 0: 582: 63.62		MACF1_HUMAN (351-1936): 4.95e-21: 105: 11.05
+	Hs
		297808 LYN_HUMAN (1-512): 0: 611: 100.00		K0754_HUMAN (1218-1826): 6.86e-10: 69: 10.48
+	Hs
		433558 LYN_HUMAN (1-512): 0: 611: 100.00		DESP_HUMAN (1555-1738): 2.9e-09: 67: 28.50
+	Hs
		164551 LCK_HUMAN (1-512): 0: 582: 63.62		SPTN2_HUMAN (5708-7163): 4.91e-17: 92.5: 14.91
+	Hs
		411637 LCK_HUMAN (1-512): 0: 582: 63.62		UTRN_HUMAN (264-1530): 1.26e-14: 84.8: 9.65
+	Hs
		411715 LCK_HUMAN (1-512): 0: 582: 63.62		SPTN1_HUMAN (269-874): 2.44e-13: 80.3: 13.42
+	Hs
		411724 LCK_HUMAN (1-512): 0: 582: 63.62		GOGB1_HUMAN (1119-1866): 1.3e-10: 71.3: 6.59
+	Hs
		411581 LCK_HUMAN (1-512): 0: 582: 63.62		DESP_HUMAN (1555-1738): 2.9e-09: 67: 28.50
+	Hs
		411983 FYN_HUMAN (1-510): 0: 576: 54.12		DESP_HUMAN (1555-1738): 2.9e-09: 67: 28.50
+	Hs
		337470 ABL1_HUMAN (32-509): 9.04e-172: 516: 37.88		SPTN1_HUMAN (269-874): 2.44e-13: 80.3: 13.42
+	Hs
		993249 PTK6_HUMAN (58-506): 6.05e-162: 468: 38.55		ACTN3_HUMAN (453-929): 1.33e-11: 74.3: 10.26