HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: ARHG5 (Q12774)
Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM)
Gene: ARHGEF5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1, PH~SH3_1, RhoGEF~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 512 Hs			1 1597
+	Hs
		442854 HCK_HUMAN (1-512): 0: 595: 70.70		NGEF_HUMAN (927-1585): 1.22e-103: 350: 32.99
+	Hs
		433781 LYN_HUMAN (1-512): 0: 611: 100.00		ITSN1_HUMAN (56-1523): 8.75e-83: 303: 12.75
+	Hs
		411580 LCK_HUMAN (1-512): 0: 582: 63.62		VAV_HUMAN (1127-1525): 1.6e-84: 298: 15.92
+	Hs
		411981 FYN_HUMAN (1-510): 0: 576: 54.12		VAV_HUMAN (1127-1525): 1.6e-84: 298: 15.92
+	Hs
		412357 FYN_HUMAN (1-510): 0: 576: 54.12		ECT2_HUMAN (1113-1497): 1.4e-83: 297: 22.14
+	Hs
		522974 SRC_HUMAN (1-510): 0: 580: 51.97		RGRF1_HUMAN (1108-1572): 2.05e-79: 290: 15.57
+	Hs
		412098 FYN_HUMAN (1-510): 0: 576: 54.12		VAV2_HUMAN (1094-1525): 8.15e-78: 279: 14.58
+	Hs
		279832 LYN_HUMAN (1-512): 0: 611: 100.00		TRIO_HUMAN (1173-1586): 6.85e-59: 227: 17.10
+	Hs
		411673 LCK_HUMAN (1-512): 0: 582: 63.62		FGD1_HUMAN (956-1497): 1.04e-66: 247: 18.31
+	Hs
		337333 ABL1_HUMAN (32-509): 9.04e-172: 516: 37.88		VAV_HUMAN (1127-1525): 1.6e-84: 298: 15.92
+	Hs
		224698 LCK_HUMAN (1-512): 0: 582: 63.62		KALRN_HUMAN (1147-1586): 2.29e-59: 229: 16.18
+	Hs
		279830 LCK_HUMAN (1-512): 0: 582: 63.62		TRIO_HUMAN (1173-1586): 6.85e-59: 227: 17.10
+	Hs
		224699 FYN_HUMAN (1-510): 0: 576: 54.12		KALRN_HUMAN (1147-1586): 2.29e-59: 229: 16.18
+	Hs
		434097 LYN_HUMAN (1-512): 0: 611: 100.00		FARP1_HUMAN (956-1530): 1.4e-48: 191: 15.59
+	Hs
		167061 FYN_HUMAN (1-510): 0: 576: 54.12		ARHGB_HUMAN (1141-1505): 3.75e-58: 223: 19.74
+	Hs
		411904 LCK_HUMAN (1-512): 0: 582: 63.62		FARP1_HUMAN (956-1530): 1.4e-48: 191: 15.59
+	Hs
		548654 TEC_HUMAN (35-505): 1.09e-160: 472: 35.48		VAV_HUMAN (1127-1525): 1.6e-84: 298: 15.92
+	Hs
		548690 BTK_HUMAN (2-505): 1.48e-156: 462: 33.86		VAV_HUMAN (1127-1525): 1.6e-84: 298: 15.92
+	Hs
		167058 ABL1_HUMAN (32-509): 9.04e-172: 516: 37.88		ARHGB_HUMAN (1141-1505): 3.75e-58: 223: 19.74