HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	10026222
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 512 Hs			1 533
+	Hs
		442821 HCK_HUMAN (1-512): 0: 595: 70.70		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		411700 LCK_HUMAN (1-512): 0: 582: 63.62		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		522951 SRC_HUMAN (1-510): 0: 580: 51.97		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		412165 FYN_HUMAN (1-510): 0: 576: 54.12		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Mm
		763395 FYN_MOUSE (1-510): 0: 576: 53.93		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Mm
		639462 LYN_MOUSE (1-512): 0: 612: 96.09		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57
+	Hs
		433917 LYN_HUMAN (1-512): 0: 611: 100.00		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Hs
		297808 LYN_HUMAN (1-512): 0: 611: 100.00		K0754_HUMAN (18-469): 5.29e-28: 121: 11.97
+	Mm
		536209 FGR_MOUSE (1-510): 0: 580: 56.03		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57
+	Mm
		763411 FYN_MOUSE (1-510): 0: 576: 53.93		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57
+	Hs
		523025 SRC_HUMAN (1-510): 0: 580: 51.97		TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50
+	Hs
		433560 LYN_HUMAN (1-512): 0: 611: 100.00		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		203198 LCK_HUMAN (1-512): 0: 582: 63.62		SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71
+	Hs
		411582 LCK_HUMAN (1-512): 0: 582: 63.62		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		522749 SRC_HUMAN (1-510): 0: 580: 51.97		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		412433 FYN_HUMAN (1-510): 0: 576: 54.12		MYO16_HUMAN (111-438): 6.65e-11: 67.4: 12.90
+	Hs
		782795 CSK_HUMAN (64-503): 1.5e-171: 493: 38.41		TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32
+	Hs
		782797 CSK_HUMAN (64-503): 1.5e-171: 493: 38.41		TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50
+	Hs
		782828 CSK_HUMAN (64-503): 1.5e-171: 493: 38.41		TENS1_HUMAN (85-512): 1.44e-22: 104: 14.61
+	Hs
		337335 ABL1_HUMAN (32-509): 9.04e-172: 516: 37.88		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92