HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: TIF1B (Q13263)
Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)
Gene: TRIM28

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	23645696
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0031625 - ubiquitin protein ligase binding GO:0045087 - innate immune response
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 512 Hs			1 835
+	Hs
		522958 SRC_HUMAN (1-510): 0: 580: 51.97		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		412173 FYN_HUMAN (1-510): 0: 576: 54.12		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		433340 YES_HUMAN (1-510): 0: 572: 54.26		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		442893 HCK_HUMAN (1-512): 0: 595: 70.70		TRIM1_HUMAN (40-589): 4.03e-64: 231: 15.36
+	Hs
		433933 LYN_HUMAN (1-512): 0: 611: 100.00		TRI63_HUMAN (53-406): 8.26e-61: 211: 15.56
+	Hs
		433984 LYN_HUMAN (1-512): 0: 611: 100.00		TRI55_HUMAN (41-610): 9.71e-50: 186: 14.21
+	Hs
		412294 FYN_HUMAN (1-510): 0: 576: 54.12		TRI63_HUMAN (53-406): 8.26e-61: 211: 15.56
+	Hs
		846541 BLK_HUMAN (1-512): 0: 544: 60.00		TRIM1_HUMAN (40-589): 4.03e-64: 231: 15.36
+	Hs
		412344 FYN_HUMAN (1-510): 0: 576: 54.12		TRI55_HUMAN (41-610): 9.71e-50: 186: 14.21
+	Hs
		433465 YES_HUMAN (1-510): 0: 572: 54.26		TRIM5_HUMAN (113-541): 7.42e-50: 185: 13.04