HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: PTK7 (Q13308)
Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7)
Gene: PTK7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0010976 - positive regulation of neuron projection development GO:0071300 - cellular response to retinoic acid
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 512 Hs			1 1070
+	Hs
		384114 LYN_HUMAN (1-512): 0: 611: 100.00		NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31
+	Hs
		384184 SRC_HUMAN (1-510): 0: 580: 51.97		NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31
+	Hs
		523201 SRC_HUMAN (1-510): 0: 580: 51.97		ALK_HUMAN (695-1067): 1.21e-52: 204: 32.90
+	Hs
		433573 LYN_HUMAN (1-512): 0: 611: 100.00		FGFR2_HUMAN (297-603): 8.71e-43: 170: 18.52
+	Hs
		522773 SRC_HUMAN (1-510): 0: 580: 51.97		FGFR2_HUMAN (297-603): 8.71e-43: 170: 18.52
+	Hs
		412008 FYN_HUMAN (1-510): 0: 576: 54.12		FGFR2_HUMAN (297-603): 8.71e-43: 170: 18.52
+	Hs
		384434 ABL2_HUMAN (14-509): 1.38e-171: 517: 36.61		NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31
+	Hs
		411995 FYN_HUMAN (1-510): 0: 576: 54.12		VGFR1_HUMAN (225-713): 1.05e-34: 146: 16.99
+	Hs
		507818 SRC_HUMAN (1-510): 0: 580: 51.97		FGFR1_HUMAN (2-231): 7.15e-34: 142: 12.41
+	Hs
		433247 YES_HUMAN (1-510): 0: 572: 54.26		VGFR1_HUMAN (225-713): 1.05e-34: 146: 16.99
+	Hs
		433229 YES_HUMAN (1-510): 0: 572: 54.26		FGFR1_HUMAN (2-231): 7.15e-34: 142: 12.41
+	Hs
		411613 LCK_HUMAN (1-512): 0: 582: 63.62		UFO_HUMAN (21-348): 3.55e-29: 127: 18.80
+	Hs
		522808 SRC_HUMAN (1-510): 0: 580: 51.97		UFO_HUMAN (21-348): 3.55e-29: 127: 18.80
+	Hs
		522932 SRC_HUMAN (1-510): 0: 580: 51.97		TYRO3_HUMAN (226-605): 4.36e-27: 121: 13.17
+	Hs
		433576 LYN_HUMAN (1-512): 0: 611: 100.00		FGFR4_HUMAN (2-127): 8.1e-14: 78.2: 17.73
+	Hs
		434019 LYN_HUMAN (1-512): 0: 611: 100.00		ROBO2_HUMAN (590-799): 3.13e-11: 70.1: 14.16
+	Hs
		412212 FYN_HUMAN (1-510): 0: 576: 54.12		NTRK2_HUMAN (43-313): 2.12e-18: 92.8: 16.12
+	Hs
		507897 ABL2_HUMAN (14-509): 1.38e-171: 517: 36.61		FGFR1_HUMAN (2-231): 7.15e-34: 142: 12.41
+	Hs
		674354 ABL2_HUMAN (14-509): 1.38e-171: 517: 36.61		UFO_HUMAN (21-348): 3.55e-29: 127: 18.80
+	Hs
		607907 ABL2_HUMAN (14-509): 1.38e-171: 517: 36.61		FGFR4_HUMAN (2-127): 8.1e-14: 78.2: 17.73