HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: SH319 (Q5HYK7)
SH3 domain-containing protein 19 (ADAM-binding protein Eve-1) (EEN-binding protein) (EBP)
Gene: SH3D19

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, PK_Tyr_Ser-Thr~SH3_9, SH2~SH3_1, SH2~SH3_2, SH3_1~SH3_1, SH3_1~SH3_2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 512 Hs			1 790
+	Hs
		433781 LYN_HUMAN (1-512): 0: 611: 100.00		ITSN1_HUMAN (417-786): 3.11e-27: 121: 18.20
+	Mm
		763403 FYN_MOUSE (1-510): 0: 576: 53.93		NCK1_MOUSE (414-659): 3.19e-29: 122: 20.29
+	Hs
		411986 FYN_HUMAN (1-510): 0: 576: 54.12		NCK1_HUMAN (414-659): 8.08e-29: 120: 19.93
+	Hs
		522887 SRC_HUMAN (1-510): 0: 580: 51.97		GRB2_HUMAN (498-718): 1.8e-24: 104: 20.27
+	Hs
		442898 HCK_HUMAN (1-512): 0: 595: 70.70		CD2AP_HUMAN (300-607): 3.02e-17: 88.2: 10.87
+	Mm
		763393 FYN_MOUSE (1-510): 0: 576: 53.93		GRB2_MOUSE (498-718): 2.72e-24: 103: 20.27
+	Hs
		433938 LYN_HUMAN (1-512): 0: 611: 100.00		SH3K1_HUMAN (477-670): 2.62e-10: 65.9: 14.72
+	Hs
		433859 LYN_HUMAN (1-512): 0: 611: 100.00		SH3R1_HUMAN (244-550): 1.54e-09: 63.7: 11.61
+	Hs
		412426 FYN_HUMAN (1-510): 0: 576: 54.12		CD2AP_HUMAN (300-607): 3.02e-17: 88.2: 10.87
+	Hs
		442869 HCK_HUMAN (1-512): 0: 595: 70.70		SH3K1_HUMAN (477-670): 2.62e-10: 65.9: 14.72
+	Hs
		411817 LCK_HUMAN (1-512): 0: 582: 63.62		SH3K1_HUMAN (477-670): 2.62e-10: 65.9: 14.72
+	Hs
		523104 SRC_HUMAN (1-510): 0: 580: 51.97		SH3K1_HUMAN (477-670): 2.62e-10: 65.9: 14.72
+	Hs
		523130 SRC_HUMAN (1-510): 0: 580: 51.97		SRBS1_HUMAN (672-788): 2.98e-09: 62.8: 33.07
+	Hs
		412296 FYN_HUMAN (1-510): 0: 576: 54.12		SH3K1_HUMAN (477-670): 2.62e-10: 65.9: 14.72
+	Hs
		557630 ABL2_HUMAN (14-509): 1.38e-171: 517: 36.61		NCK1_HUMAN (414-659): 8.08e-29: 120: 19.93
+	Hs
		209001 ABL2_HUMAN (14-509): 1.38e-171: 517: 36.61		NCK2_HUMAN (414-652): 5.41e-28: 118: 20.36
+	Hs
		454842 FGR_HUMAN (1-510): 0: 562: 53.61		SH3K1_HUMAN (477-670): 2.62e-10: 65.9: 14.72
+	Ce
		220205 SRC2_CAEEL (1-510): 0: 530: 45.74		SEM5_CAEEL (498-732): 1.75e-18: 87.1: 22.46
+	Hs
		298959 ABL2_HUMAN (14-509): 1.38e-171: 517: 36.61		SRBS2_HUMAN (612-787): 2.26e-15: 82.6: 22.53
+	Hs
		235483 ABL2_HUMAN (14-509): 1.38e-171: 517: 36.61		VINEX_HUMAN (621-788): 1.29e-13: 76.7: 18.82