HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: MRCKA (Q5VT25)
Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)
Gene: CDC42BPA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~Pkinase, C1_1~SH2
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006468 - protein phosphorylation GO:0070062 - extracellular exosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 512 Hs			1 1732
+	Hs
		411758 LCK_HUMAN (1-512): 0: 582: 63.62		MRCKA_HUMAN (1-1732): 0: 1615: 100.00
+	Hs
		434101 LYN_HUMAN (1-512): 0: 611: 100.00		MRCKB_HUMAN (1-1731): 0: 1417: 60.38
+	Hs
		411908 LCK_HUMAN (1-512): 0: 582: 63.62		MRCKB_HUMAN (1-1731): 0: 1417: 60.38
+	Hs
		433609 LYN_HUMAN (1-512): 0: 611: 100.00		AKT2_HUMAN (13-391): 2.91e-129: 414: 30.65
+	Hs
		522810 SRC_HUMAN (1-510): 0: 580: 51.97		AKT1_HUMAN (13-404): 1.23e-128: 413: 31.51
+	Mm
		403418 SRC_MOUSE (1-510): 0: 577: 52.07		AKT1_MOUSE (13-404): 4.42e-129: 414: 31.27
+	Hs
		412046 FYN_HUMAN (1-510): 0: 576: 54.12		AKT1_HUMAN (13-404): 1.23e-128: 413: 31.51
+	Hs
		434067 LYN_HUMAN (1-512): 0: 611: 100.00		TNIK_HUMAN (53-905): 4.35e-97: 346: 15.60
+	Hs
		434089 LYN_HUMAN (1-512): 0: 611: 100.00		ST38L_HUMAN (66-416): 1.26e-88: 299: 43.15
+	Hs
		681710 CSK_HUMAN (64-503): 1.5e-171: 493: 38.41		AKT1_HUMAN (13-404): 1.23e-128: 413: 31.51
+	Hs
		411727 LCK_HUMAN (1-512): 0: 582: 63.62		STK38_HUMAN (66-404): 1.24e-89: 302: 45.07
+	Hs
		681838 PTK6_HUMAN (58-506): 6.05e-162: 468: 38.55		AKT1_HUMAN (13-404): 1.23e-128: 413: 31.51
+	Hs
		433510 YES_HUMAN (1-510): 0: 572: 54.26		ST38L_HUMAN (66-416): 1.26e-88: 299: 43.15
+	Hs
		523170 SRC_HUMAN (1-510): 0: 580: 51.97		LATS2_HUMAN (65-376): 3.53e-75: 275: 41.23
+	Hs
		789133 FRK_HUMAN (32-506): 0: 528: 48.47		LATS2_HUMAN (65-376): 3.53e-75: 275: 41.23
+	Hs
		337568 ABL1_HUMAN (32-509): 9.04e-172: 516: 37.88		LATS2_HUMAN (65-376): 3.53e-75: 275: 41.23
+	Hs
		433749 LYN_HUMAN (1-512): 0: 611: 100.00		ROCK1_HUMAN (361-1052): 1.07e-20: 101: 11.28