HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: ABI1 (Q8IZP0)
Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)
Gene: ABI1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	34079125, 20598684
Identification Methods	proximity labelling technology, array technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway GO:0008285 - negative regulation of cell population proliferation GO:0017124 - SH3 domain binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 512 Hs			1 508
+	Hs
		442853 HCK_HUMAN (1-512): 0: 595: 70.70		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		411788 LCK_HUMAN (1-512): 0: 582: 63.62		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		523060 SRC_HUMAN (1-510): 0: 580: 51.97		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Mm
		639446 LYN_MOUSE (1-512): 0: 612: 96.09		SRC8_MOUSE (291-502): 1.17e-33: 136: 20.64
+	Hs
		203198 LCK_HUMAN (1-512): 0: 582: 63.62		SYNJ1_HUMAN (38-463): 1.36e-41: 161: 11.55
+	Mm
		639438 LYN_MOUSE (1-512): 0: 612: 96.09		HCLS1_MOUSE (266-503): 2.48e-29: 122: 20.07
+	Hs
		442894 HCK_HUMAN (1-512): 0: 595: 70.70		ASAP1_HUMAN (107-505): 8.23e-33: 135: 16.83
+	Hs
		433732 LYN_HUMAN (1-512): 0: 611: 100.00		MYO1E_HUMAN (305-503): 2.96e-27: 118: 22.67
+	Hs
		522981 SRC_HUMAN (1-510): 0: 580: 51.97		SRC8_HUMAN (291-502): 1.23e-34: 138: 20.72
+	Hs
		523197 SRC_HUMAN (1-510): 0: 580: 51.97		ASAP1_HUMAN (107-505): 8.23e-33: 135: 16.83
+	Mm
		411921 LCK_MOUSE (1-512): 0: 591: 63.81		HCLS1_MOUSE (266-503): 2.48e-29: 122: 20.07
+	Hs
		433551 LYN_HUMAN (1-512): 0: 611: 100.00		HCLS1_HUMAN (342-503): 7.7e-19: 91.2: 22.17
+	Mm
		763381 FYN_MOUSE (1-510): 0: 576: 53.93		HCLS1_MOUSE (266-503): 2.48e-29: 122: 20.07
+	Hs
		297808 LYN_HUMAN (1-512): 0: 611: 100.00		K0754_HUMAN (80-400): 5.9e-17: 86.7: 7.60
+	Mm
		639449 LYN_MOUSE (1-512): 0: 612: 96.09		DBNL_MOUSE (274-503): 6.55e-16: 81.9: 22.88
+	Hs
		166024 FYN_HUMAN (1-510): 0: 576: 54.12		SYNJ2_HUMAN (39-458): 2.1e-26: 115: 13.88
+	Hs
		433807 LYN_HUMAN (1-512): 0: 611: 100.00		SH319_HUMAN (446-503): 2.42e-10: 65.1: 36.21
+	Hs
		433781 LYN_HUMAN (1-512): 0: 611: 100.00		ITSN1_HUMAN (399-504): 1.82e-09: 62.5: 20.35
+	Hs
		442898 HCK_HUMAN (1-512): 0: 595: 70.70		CD2AP_HUMAN (451-508): 2.26e-14: 77.9: 40.68
+	Hs
		433859 LYN_HUMAN (1-512): 0: 611: 100.00		SH3R1_HUMAN (244-503): 3.15e-09: 61.6: 17.28