HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: TBCK (Q8TEA7)
TBC domain-containing protein kinase-like protein (FERRY endosomal RAB5 effector complex subunit 1) (Fy-1)
Gene: TBCK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 512 Hs			1 893
+	Hs
		523078 SRC_HUMAN (1-510): 0: 580: 51.97		TBCK_HUMAN (1-893): 0: 721: 100.00
+	Hs
		789128 FRK_HUMAN (32-506): 0: 528: 48.47		TBCK_HUMAN (1-893): 0: 721: 100.00
+	Hs
		433850 LYN_HUMAN (1-512): 0: 611: 100.00		MARK2_HUMAN (2-470): 3.46e-114: 369: 18.58
+	Hs
		411778 LCK_HUMAN (1-512): 0: 582: 63.62		MARK2_HUMAN (2-470): 3.46e-114: 369: 18.58
+	Hs
		433589 LYN_HUMAN (1-512): 0: 611: 100.00		MARK3_HUMAN (27-410): 8.27e-80: 275: 21.13
+	Hs
		522867 SRC_HUMAN (1-510): 0: 580: 51.97		KS6A3_HUMAN (2-286): 3.69e-83: 284: 18.58
+	Hs
		412205 FYN_HUMAN (1-510): 0: 576: 54.12		KS6A1_HUMAN (5-293): 1.72e-83: 285: 18.40
+	Hs
		412095 FYN_HUMAN (1-510): 0: 576: 54.12		KS6A3_HUMAN (2-286): 3.69e-83: 284: 18.58
+	Hs
		411606 LCK_HUMAN (1-512): 0: 582: 63.62		MARK3_HUMAN (27-410): 8.27e-80: 275: 21.13
+	Hs
		412203 FYN_HUMAN (1-510): 0: 576: 54.12		KS6A2_HUMAN (2-273): 9.1e-82: 280: 18.02
+	Hs
		433360 YES_HUMAN (1-510): 0: 572: 54.26		KS6A2_HUMAN (2-273): 9.1e-82: 280: 18.02
+	Hs
		789116 FRK_HUMAN (32-506): 0: 528: 48.47		KS6A1_HUMAN (5-293): 1.72e-83: 285: 18.40
+	Hs
		433949 LYN_HUMAN (1-512): 0: 611: 100.00		MARK4_HUMAN (31-295): 9e-16: 84: 26.52
+	Hs
		412167 FYN_HUMAN (1-510): 0: 576: 54.12		AAPK1_HUMAN (99-294): 1.55e-15: 82.8: 30.30
+	Hs
		320504 FRK_HUMAN (32-506): 0: 528: 48.47		OXSR1_HUMAN (37-275): 3.73e-16: 84.7: 28.24