HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: GAB3 (Q8WWW8)
GRB2-associated-binding protein 3 (GRB2-associated binder 3) (Growth factor receptor bound protein 2-associated protein 3)
Gene: GAB3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	11739737, 18235045
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 512 Hs			1 586
+	Hs
		523086 SRC_HUMAN (1-510): 0: 580: 51.97		GAB3_HUMAN (1-586): 1.2e-108: 339: 100.00
+	Hs
		434086 LYN_HUMAN (1-512): 0: 611: 100.00		GAB2_HUMAN (2-585): 1.27e-75: 255: 31.29
+	Hs
		434015 LYN_HUMAN (1-512): 0: 611: 100.00		PKHA5_HUMAN (4-580): 9.83e-67: 237: 12.52
+	Mm
		639464 LYN_MOUSE (1-512): 0: 612: 96.09		GAB2_MOUSE (2-585): 2.96e-68: 235: 32.62
+	Hs
		523213 SRC_HUMAN (1-510): 0: 580: 51.97		GAB2_HUMAN (2-585): 1.27e-75: 255: 31.29
+	Hs
		411861 LCK_HUMAN (1-512): 0: 582: 63.62		PKHA5_HUMAN (4-580): 9.83e-67: 237: 12.52
+	Hs
		433750 LYN_HUMAN (1-512): 0: 611: 100.00		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Hs
		433831 LYN_HUMAN (1-512): 0: 611: 100.00		PKHA7_HUMAN (5-478): 7.4e-49: 185: 11.91
+	Hs
		442825 HCK_HUMAN (1-512): 0: 595: 70.70		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Hs
		411709 LCK_HUMAN (1-512): 0: 582: 63.62		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Hs
		522965 SRC_HUMAN (1-510): 0: 580: 51.97		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Hs
		411764 LCK_HUMAN (1-512): 0: 582: 63.62		PKHA7_HUMAN (5-478): 7.4e-49: 185: 11.91
+	Hs
		297808 LYN_HUMAN (1-512): 0: 611: 100.00		K0754_HUMAN (100-573): 5.03e-30: 128: 11.04
+	Hs
		411897 LCK_HUMAN (1-512): 0: 582: 63.62		PKHA6_HUMAN (4-458): 2.39e-36: 147: 13.21
+	Hs
		433560 LYN_HUMAN (1-512): 0: 611: 100.00		MUC1_HUMAN (128-574): 8.61e-16: 83.3: 10.53
+	Hs
		433861 LYN_HUMAN (1-512): 0: 611: 100.00		PHLB2_HUMAN (1-112): 4.39e-10: 65.1: 28.57
+	Hs
		411582 LCK_HUMAN (1-512): 0: 582: 63.62		MUC1_HUMAN (128-574): 8.61e-16: 83.3: 10.53
+	Hs
		522749 SRC_HUMAN (1-510): 0: 580: 51.97		MUC1_HUMAN (128-574): 8.61e-16: 83.3: 10.53
+	Hs
		203198 LCK_HUMAN (1-512): 0: 582: 63.62		SYNJ1_HUMAN (110-572): 1.24e-12: 73.3: 9.79
+	Hs
		411772 LCK_HUMAN (1-512): 0: 582: 63.62		MPRIP_HUMAN (8-301): 3.32e-10: 65.2: 13.38