HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	15707590
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0017124 - SH3 domain binding GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 512 Hs			1 665
+	Hs
		442869 HCK_HUMAN (1-512): 0: 595: 70.70		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		411817 LCK_HUMAN (1-512): 0: 582: 63.62		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		523104 SRC_HUMAN (1-510): 0: 580: 51.97		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		412296 FYN_HUMAN (1-510): 0: 576: 54.12		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		454842 FGR_HUMAN (1-510): 0: 562: 53.61		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		442898 HCK_HUMAN (1-512): 0: 595: 70.70		CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22
+	Hs
		412426 FYN_HUMAN (1-510): 0: 576: 54.12		CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22
+	Hs
		523022 SRC_HUMAN (1-510): 0: 580: 51.97		SPD2A_HUMAN (1-631): 1.05e-46: 180: 14.72
+	Hs
		433781 LYN_HUMAN (1-512): 0: 611: 100.00		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Hs
		522887 SRC_HUMAN (1-510): 0: 580: 51.97		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		411986 FYN_HUMAN (1-510): 0: 576: 54.12		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Mm
		763403 FYN_MOUSE (1-510): 0: 576: 53.93		NCK1_MOUSE (104-421): 1.23e-32: 131: 15.93
+	Mm
		763393 FYN_MOUSE (1-510): 0: 576: 53.93		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		433859 LYN_HUMAN (1-512): 0: 611: 100.00		SH3R1_HUMAN (241-599): 5.37e-12: 71.2: 13.28
+	Hs
		433807 LYN_HUMAN (1-512): 0: 611: 100.00		SH319_HUMAN (164-469): 4.12e-09: 61.9: 13.31
+	Hs
		411580 LCK_HUMAN (1-512): 0: 582: 63.62		VAV_HUMAN (84-158): 4.66e-13: 74.7: 28.95
+	Hs
		411981 FYN_HUMAN (1-510): 0: 576: 54.12		VAV_HUMAN (84-158): 4.66e-13: 74.7: 28.95
+	Ce
		220205 SRC2_CAEEL (1-510): 0: 530: 45.74		SEM5_CAEEL (2-167): 1.56e-29: 118: 21.08
+	Hs
		209001 ABL2_HUMAN (14-509): 1.38e-171: 517: 36.61		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Hs
		235483 ABL2_HUMAN (14-509): 1.38e-171: 517: 36.61		VINEX_HUMAN (67-445): 2.37e-15: 81.7: 19.82