HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: NRBP2 (Q9NSY0)
Nuclear receptor-binding protein 2 (Transformation-related gene 16 protein) (TRG-16)
Gene: NRBP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 512 Hs			1 501
+	Hs
		433609 LYN_HUMAN (1-512): 0: 611: 100.00		AKT2_HUMAN (3-354): 1.14e-118: 358: 15.07
+	Hs
		433850 LYN_HUMAN (1-512): 0: 611: 100.00		MARK2_HUMAN (11-490): 6.7e-115: 358: 13.73
+	Hs
		433949 LYN_HUMAN (1-512): 0: 611: 100.00		MARK4_HUMAN (9-494): 3.47e-114: 355: 13.62
+	Hs
		434053 LYN_HUMAN (1-512): 0: 611: 100.00		KS6B2_HUMAN (17-415): 1.16e-115: 351: 15.63
+	Hs
		411778 LCK_HUMAN (1-512): 0: 582: 63.62		MARK2_HUMAN (11-490): 6.7e-115: 358: 13.73
+	Hs
		522810 SRC_HUMAN (1-510): 0: 580: 51.97		AKT1_HUMAN (9-367): 5.98e-119: 359: 14.63
+	Mm
		403418 SRC_MOUSE (1-510): 0: 577: 52.07		AKT1_MOUSE (9-367): 2.44e-119: 360: 14.63
+	Hs
		412046 FYN_HUMAN (1-510): 0: 576: 54.12		AKT1_HUMAN (9-367): 5.98e-119: 359: 14.63
+	Hs
		523184 SRC_HUMAN (1-510): 0: 580: 51.97		KS6B2_HUMAN (17-415): 1.16e-115: 351: 15.63
+	Hs
		412392 FYN_HUMAN (1-510): 0: 576: 54.12		KS6B2_HUMAN (17-415): 1.16e-115: 351: 15.63
+	Hs
		412423 FYN_HUMAN (1-510): 0: 576: 54.12		WNK2_HUMAN (2-314): 1.91e-103: 342: 29.91
+	Hs
		412163 FYN_HUMAN (1-510): 0: 576: 54.12		STK4_HUMAN (14-500): 1.5e-111: 340: 14.89
+	Hs
		412167 FYN_HUMAN (1-510): 0: 576: 54.12		AAPK1_HUMAN (37-476): 4.17e-99: 311: 15.25
+	Hs
		433739 LYN_HUMAN (1-512): 0: 611: 100.00		PAK1_HUMAN (4-317): 4.56e-76: 250: 23.57
+	Hs
		433740 LYN_HUMAN (1-512): 0: 611: 100.00		PAK2_HUMAN (4-317): 7.65e-70: 233: 22.85
+	Hs
		442822 HCK_HUMAN (1-512): 0: 595: 70.70		PAK2_HUMAN (4-317): 7.65e-70: 233: 22.85
+	Hs
		411702 LCK_HUMAN (1-512): 0: 582: 63.62		PAK2_HUMAN (4-317): 7.65e-70: 233: 22.85
+	Hs
		522955 SRC_HUMAN (1-510): 0: 580: 51.97		PAK2_HUMAN (4-317): 7.65e-70: 233: 22.85
+	Hs
		412169 FYN_HUMAN (1-510): 0: 576: 54.12		PAK2_HUMAN (4-317): 7.65e-70: 233: 22.85
+	Hs
		433338 YES_HUMAN (1-510): 0: 572: 54.26		PAK2_HUMAN (4-317): 7.65e-70: 233: 22.85