Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.72 1.00 0.849

The method score is based on:

Property Details
Experiments 32062451, 12787916, 20473317
Identification Methods affinity chromatography technology, proximity labelling technology, two hybrid, x-ray crystallography
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Cadherin~Cadherin, Cadherin~RET_CLD1, Cadherin~RET_CLD3, Cadherin~RET_CLD4, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, RET_CLD1~RET_CLD4, RET_CLD3~RET_CLD4
Common GO terms GO:0000165 - MAPK cascade
GO:0001657 - ureteric bud development
GO:0001755 - neural crest cell migration
GO:0001838 - embryonic epithelial tube formation
GO:0004713 - protein tyrosine kinase activity
and 45 others

more...

Homologous interactions 19

Homologous interactions

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024