HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: CLUS (P10909)
Clusterin (Aging-associated gene 4 protein) (Apolipoprotein J) (Apo-J) (Complement cytolysis inhibitor) (CLI) (Complement-associated protein SP-40,40) (Ku70-binding protein 1) (NA1/NA2) (Sulfated glycoprotein 2) (SGP-2) (Testosterone-repressed prostate message 2) (TRPM-2) [Cleaved into: Clusterin beta chain (ApoJalpha) (Complement cytolysis inhibitor a chain) (SP-40,40 beta-chain); Clusterin alpha chain (ApoJbeta) (Complement cytolysis inhibitor b chain) (SP-40,40 alpha-chain)]
Gene: CLU

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	32062451, 35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0010628 - positive regulation of gene expression
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 1114 Hs			1 449
+	Hs
		500700 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		CLUS_HUMAN (1-449): 0: 697: 100.00
+	Hs
		337837 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		CLUS_HUMAN (1-449): 0: 697: 100.00
+	Hs
		500798 NTRK3_HUMAN (638-1020): 2.11e-106: 355: 31.19		CLUS_HUMAN (1-449): 0: 697: 100.00