HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0010976 - positive regulation of neuron projection development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 377
+	Hs
		208976 RET_HUMAN (1-1114): 0: 1295: 100.00		NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24
+	Hs
		434140 RET_HUMAN (1-1114): 0: 1295: 100.00		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		129170 RET_HUMAN (1-1114): 0: 1295: 100.00		P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61
+	Mm
		643062 RET_MOUSE (1-1114): 0: 1275: 83.24		P85A_MOUSE (241-376): 1.59e-22: 101: 19.57
+	Hs
		434125 RET_HUMAN (1-1114): 0: 1295: 100.00		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		434170 RET_HUMAN (1-1114): 0: 1295: 100.00		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Mm
		403421 RET_MOUSE (1-1114): 0: 1275: 83.24		SRC_MOUSE (5-114): 1.55e-15: 79.7: 22.32
+	Hs
		507832 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00
+	Hs
		208983 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24
+	Hs
		507897 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05
+	Hs
		601463 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		129199 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61
+	Hs
		412008 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		507870 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		129184 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61
+	Hs
		522773 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		601492 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		601605 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		ITSN2_HUMAN (7-85): 2.68e-12: 70.6: 24.05
+	Hs
		507818 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		433229 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		YES_HUMAN (112-218): 4.18e-11: 66.1: 19.27