HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: PLCG1 (P19174)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	32062451, 8628282
Identification Methods	proximity labelling technology, pull down, competition binding
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005509 - calcium ion binding GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 1290
+	Hs
		580923 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		507843 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		581010 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Mm
		729415 VGFR2_MOUSE (344-1105): 1.6e-146: 475: 23.94		PLCG1_MOUSE (1-1288): 0: 1302: 96.12
+	Hs
		580927 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		337912 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		383601 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Mm
		1112476 NTRK1_MOUSE (381-1018): 1.02e-148: 466: 24.73		PLCG1_MOUSE (1-1288): 0: 1302: 96.12
+	Hs
		580949 VGFR2_HUMAN (344-1105): 2.13e-137: 451: 23.91		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Rn
		499160 FGFR1_RAT (501-1061): 9.97e-146: 459: 32.44		PLCG1_RAT (1-1290): 0: 1299: 96.90
+	Hs
		507835 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		PLCG2_HUMAN (18-1287): 0: 1128: 49.45
+	Hs
		562648 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		PLCG2_HUMAN (18-1287): 0: 1128: 49.45
+	Hs
		337886 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		PLCG2_HUMAN (18-1287): 0: 1128: 49.45
+	Hs
		383591 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		PLCG2_HUMAN (18-1287): 0: 1128: 49.45
+	At
		83487 Y1756_ARATH (244-1039): 0: 597: 14.05		PLCD2_ARATH (836-1211): 1.32e-77: 270: 20.65
+	At
		286282 Y2899_ARATH (249-1031): 5.95e-178: 545: 13.48		PLCD2_ARATH (836-1211): 1.32e-77: 270: 20.65
+	At
		84145 Y2289_ARATH (234-1037): 1.59e-171: 528: 13.77		PLCD2_ARATH (836-1211): 1.32e-77: 270: 20.65
+	Hs
		609614 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		PLCL2_HUMAN (840-1240): 4.61e-92: 324: 29.23
+	Hs
		338511 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		PLCH1_HUMAN (847-1284): 8.88e-86: 310: 27.09
+	Mm
		719299 EGFR_MOUSE (426-1113): 8.96e-142: 459: 22.83		PTN11_MOUSE (546-769): 4.4e-68: 243: 26.86