HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.920

Property	Details
Experiments	32062451, 28213521, 9047384, 8183561, 15677445
Identification Methods	proximity labelling technology, affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0043410 - positive regulation of MAPK cascade GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 583
+	Hs
		434220 RET_HUMAN (1-1114): 0: 1295: 100.00		SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53
+	Hs
		208976 RET_HUMAN (1-1114): 0: 1295: 100.00		NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83
+	Hs
		434130 RET_HUMAN (1-1114): 0: 1295: 100.00		NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30
+	Hs
		434140 RET_HUMAN (1-1114): 0: 1295: 100.00		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		434194 RET_HUMAN (1-1114): 0: 1295: 100.00		GRB7_HUMAN (371-563): 3.91e-33: 135: 21.57
+	Mm
		643062 RET_MOUSE (1-1114): 0: 1275: 83.24		P85A_MOUSE (300-581): 6.66e-38: 151: 15.99
+	Hs
		129170 RET_HUMAN (1-1114): 0: 1295: 100.00		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		434170 RET_HUMAN (1-1114): 0: 1295: 100.00		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		601467 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		507872 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		507999 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		GRB14_HUMAN (66-579): 1.66e-73: 246: 14.41
+	Hs
		507829 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		VAV_HUMAN (163-578): 1.81e-54: 200: 12.25
+	Hs
		208983 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83
+	Hs
		601463 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		507832 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30
+	Hs
		507870 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		129199 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		129184 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		601492 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		507939 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48