HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: RADI (P35241)
Radixin
Gene: RDX

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane GO:0010628 - positive regulation of gene expression GO:0030335 - positive regulation of cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 583
+	Hs
		434144 RET_HUMAN (1-1114): 0: 1295: 100.00		MERL_HUMAN (2-583): 1.72e-151: 450: 45.30
+	Hs
		507828 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		EZRI_HUMAN (1-583): 3.17e-166: 487: 76.28
+	Hs
		507885 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		RADI_HUMAN (1-583): 3.49e-166: 487: 100.00
+	Hs
		609192 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		RADI_HUMAN (1-583): 3.49e-166: 487: 100.00
+	Hs
		507865 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		MOES_HUMAN (1-583): 2.8e-161: 474: 80.96
+	Hs
		337871 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		EZRI_HUMAN (1-583): 3.17e-166: 487: 76.28
+	Hs
		338027 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		RADI_HUMAN (1-583): 3.49e-166: 487: 100.00
+	Hs
		383579 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		EZRI_HUMAN (1-583): 3.17e-166: 487: 76.28
+	Hs
		383651 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		RADI_HUMAN (1-583): 3.49e-166: 487: 100.00
+	Hs
		384207 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		EZRI_HUMAN (1-583): 3.17e-166: 487: 76.28
+	Hs
		383621 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		MOES_HUMAN (1-583): 2.8e-161: 474: 80.96
+	Hs
		507884 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		MERL_HUMAN (2-583): 1.72e-151: 450: 45.30
+	Hs
		338026 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		MERL_HUMAN (2-583): 1.72e-151: 450: 45.30
+	Hs
		383650 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		MERL_HUMAN (2-583): 1.72e-151: 450: 45.30
+	Hs
		505551 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		EPB41_HUMAN (3-553): 1.19e-125: 392: 20.48
+	Hs
		384164 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		EPB41_HUMAN (3-553): 1.19e-125: 392: 20.48
+	Hs
		204585 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		E41L2_HUMAN (2-543): 1.11e-118: 376: 19.46
+	Hs
		338978 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		E41L1_HUMAN (3-495): 9.26e-119: 374: 21.94
+	Hs
		299238 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		FARP2_HUMAN (2-582): 1.86e-110: 356: 18.76
+	Hs
		383622 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		PTN3_HUMAN (18-295): 4.04e-34: 140: 32.16