HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	32062451, 9393871
Identification Methods	proximity labelling technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 304
+	Hs
		434155 RET_HUMAN (1-1114): 0: 1295: 100.00		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		434135 RET_HUMAN (1-1114): 0: 1295: 100.00		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		434170 RET_HUMAN (1-1114): 0: 1295: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Rn
		102579 RET_RAT (1-1114): 0: 1316: 85.29		Q80ZE7_RAT (2-196): 7.4e-12: 67.9: 15.49
+	Hs
		208976 RET_HUMAN (1-1114): 0: 1295: 100.00		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		434130 RET_HUMAN (1-1114): 0: 1295: 100.00		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		507901 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Mm
		601624 FGFR2_MOUSE (501-1065): 3.92e-151: 473: 32.95		CRKL_MOUSE (2-302): 6.92e-57: 187: 47.10
+	Hs
		507902 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Mm
		555262 FGFR1_MOUSE (501-1061): 4.1e-150: 471: 32.61		CRKL_MOUSE (2-302): 6.92e-57: 187: 47.10
+	Hs
		507829 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		VAV_HUMAN (11-189): 6.6e-47: 170: 28.21
+	Hs
		580923 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Mm
		729415 VGFR2_MOUSE (344-1105): 1.6e-146: 475: 23.94		PLCG1_MOUSE (2-302): 1.1e-26: 112: 15.43
+	Hs
		601492 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		507843 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		507835 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89
+	Hs
		507939 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		601605 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		ITSN2_HUMAN (189-304): 5.82e-12: 68.3: 11.86
+	Hs
		208983 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		507832 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00