HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	28794017
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 1319
+	Hs
		601478 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		507904 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		808132 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		609205 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		338105 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		384459 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		338861 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Hs
		338634 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32
+	Hs
		1071010 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86
+	Hs
		338959 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86
+	Hs
		125077 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91
+	Hs
		1070998 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42
+	Hs
		338840 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42
+	Dr
		1109027 FGR1A_DANRE (501-1063): 1.19e-147: 464: 31.60		Q3KRP0_DANRE (404-835): 1.68e-24: 113: 13.92
+	Mm
		601625 FGFR2_MOUSE (501-1065): 3.92e-151: 473: 32.95		SMUF1_MOUSE (539-719): 1.75e-21: 103: 18.65
+	Hs
		601595 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82
+	Hs
		338999 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86
+	Hs
		383984 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86
+	Hs
		339005 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82
+	Hs
		339072 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		HECW2_HUMAN (434-992): 3.07e-10: 67.1: 13.83