HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: KS6A3 (P51812)
Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2)
Gene: RPS6KA3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 740
+	Hs
		601482 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		KS6A3_HUMAN (1-740): 0: 844: 100.00
+	Hs
		507919 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		KS6A3_HUMAN (1-740): 0: 844: 100.00
+	Hs
		609219 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		KS6A3_HUMAN (1-740): 0: 844: 100.00
+	Hs
		338157 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		KS6A3_HUMAN (1-740): 0: 844: 100.00
+	Hs
		384525 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		KS6A3_HUMAN (1-740): 0: 844: 100.00
+	Hs
		601517 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		KS6A1_HUMAN (1-740): 0: 783: 77.90
+	Hs
		508016 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		KS6A1_HUMAN (1-740): 0: 783: 77.90
+	Rn
		979772 FGFR1_RAT (501-1061): 9.97e-146: 459: 32.44		KS6A1_RAT (1-740): 0: 785: 78.17
+	Hs
		338465 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		KS6A1_HUMAN (1-740): 0: 783: 77.90
+	Hs
		384892 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		KS6A1_HUMAN (1-740): 0: 783: 77.90
+	At
		85160 PAM74_ARATH (227-1039): 1.43e-168: 521: 12.63		CDPK7_ARATH (7-327): 2.18e-114: 357: 22.42
+	Hs
		507876 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		AKT1_HUMAN (327-739): 2.87e-125: 383: 21.02
+	Hs
		338005 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		AKT2_HUMAN (327-739): 1.82e-126: 387: 21.76
+	Hs
		338004 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		AKT1_HUMAN (327-739): 2.87e-125: 383: 21.02
+	Hs
		383640 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		AKT1_HUMAN (327-739): 2.87e-125: 383: 21.02
+	Hs
		507838 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		KAPCA_HUMAN (409-714): 2.99e-117: 358: 28.84
+	Hs
		337895 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		KAPCA_HUMAN (409-714): 2.99e-117: 358: 28.84
+	Hs
		601516 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		KS6A2_HUMAN (7-327): 3.91e-100: 326: 24.02
+	Hs
		384267 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		KAPCB_HUMAN (409-714): 3.04e-116: 355: 29.15
+	Hs
		508015 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		KS6A2_HUMAN (7-327): 3.91e-100: 326: 24.02